ReviewPediatric research2016
Impaired cerebral development in fetuses with congenital cardiovascular malformations: Is it the result of inadequate glucose supply?
Review in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease.Prenatal diagnosis · 2026Review
- Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025Review
- Fetal Cerebrovascular Response to Maternal Hyperoxia Testing and Association With Brain Growth and Postnatal Brain Injury in Congenital Heart Disease.Journal of the American Heart Association · 2025Article
- Atoh1 mediated disturbance of neuronal maturation by perinatal hypoxia induces cognitive deficits.Communications biology · 2024Article
- Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries.Biomedicines · 2024Article
- Total and Regional Brain Volumes in Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2024Article
- Article
- Maternal hyperoxygenation in congenital heart disease.Translational pediatrics · 2021Review
- Fetal brain issues in congenital heart disease.Translational pediatrics · 2021Review
- Fetal cerebrovascular response to maternal hyperoxygenation in congenital heart disease: effect of cardiac physiology.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Article
- Fetal Cerebral Oxygenation Is Impaired in Congenital Heart Disease and Shows Variable Response to Maternal Hyperoxia.Journal of the American Heart Association · 2021Article
- Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease.Pediatric cardiology · 2021Review
- Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry.Scientific reports · 2020Article
- The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care.Pediatric neurology · 2020Review
- Maternal hyperoxygenation for the human fetus: should studies be curtailed?Pediatric research · 2020Review
- Neuroimaging findings in newborns with congenital heart disease prior to surgery: an observational study.Archives of disease in childhood · 2019Observational
- Placental MRI: Developing Accurate Quantitative Measures of Oxygenation.Topics in magnetic resonance imaging : TMRI · 2019Review
- Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Growth patterns and cerebroplacental hemodynamics in fetuses with congenital heart disease.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2019Article
- Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep.The Journal of thoracic and cardiovascular surgery · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral development may be impaired in fetuses with congenital cardiovascular malformations, particularly hypoplastic left heart syndrome (HLHS) and aortopulmonary transposition (APT). The decreased cerebral arterial pusatility index observed in some of these fetuses led to the belief that cerebral vascular resistance was reduced as a result of arterial hypoxemia and cerebral hypoxia is thought to be responsible for impaired cerebral growth. However, other hemodynamic factors could affect pulsatility index. I propose that cerebral blood flow is reduced in fetuses with HLHS and that reduced glucose, rather than oxygen, delivery interferes with cerebral development. This is based on the fact that most of these fetuses do not have lactate accumulation in the brain.In fetuses with APT, umbilical venous blood, containing oxygen and glucose derived across the placenta, is distributed to the lungs and lower body; venous blood, with low oxygen and glucose content, is delivered to the ascending aorta and brain. Oxygen and glucose delivery may further be reduced by decreased cerebral blood flow resulting from run-off of aortic blood through the ductus arteriosus to the pulmonary circulation during diastole. In APT fetuses, lack of lactate in the brain also supports my proposal that glucose deficiency interferes with cerebral development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.