Evidence map›Paper›PMID 27054959›Full record

Trial reportPloS one2016

Mean Platelet Volume, Vitamin D and C Reactive Protein Levels in Normal Weight Children with Primary Snoring and Obstructive Sleep Apnea Syndrome.

Anna Maria Zicari, Francesca Occasi, Federica Di Mauro, Valeria Lollobrigida, Marco Di Fraia, Vincenzo Savastano, Lorenzo Loffredo, Francesco Nicita, Alberto Spalice, Marzia Duse

Open access · goldAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  6. Article
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  10. Coagulation and Fibrinolysis in Obstructive Sleep Apnoea.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anna Maria ZicariDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Francesca OccasiDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Federica Di MauroDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Valeria LollobrigidaDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Marco Di FraiaDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Vincenzo SavastanoDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Lorenzo LoffredoDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Francesco NicitaDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Alberto SpaliceDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Marzia DuseDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStudies on Mean Platelet Volume (MPV) in children with Sleep Disordered Breathing (SDB) report conflicting results and the hypothesis of an intermittent hypoxemia leading to a systemic inflammation is reaching consensus. Vitamin D exerts anti-inflammatory properties and its deficiency has been supposed to play a role in sleep disorders. Emerging interest is rising about Primary Snoring (PS) since it is reasonable that also undetectable alteration of hypoxia might predispose to an increased production of inflammatory mediators. In this perspective, in a group of children affected by SDB, our aim was to investigate MPV, vitamin D and C Reactive Protein (CRP) levels, which had been previously evaluated separately in different studies focused only on Obstructive Sleep Apnea Syndrome (OSAS). MATERIALS AND

methodsWe enrolled 137 children: 70 healthy controls (HC), 67 affected by SDB undergoing a polysomnographic evaluation, 22 with a diagnosis of PS and 45 with a diagnosis of OSAS. All patients underwent routine biochemical evaluations including blood cell counts, CRP and vitamin D.

resultsChildren affected by SDB had a mean age of 8.49±2.19 and were prevalently males (23 females, 34%; 44 males, 66%). MPV levels were higher in OSAS and PS when compared to HC; platelet count (PLT) and CRP levels were higher while Vitamin D levels were lower in children with SDB when compared to HC. MPV levels were correlated with PLT (r = -0.54; p<0.001), vitamin D (r = -0.39; p<0.001) and CRP (r = 0.21; p<0.01). A multiple regression was run to predict MPV levels from vitamin D, CRP and PLT and these variables significantly predicted MPV (F = 17.42, p<0.0001; adjusted R2 = 0.37). Only platelet count and vitamin D added statistically significantly to the prediction (p<0.05).

conclusionThe present study provides evidence of higher MPV and lower vitamin D levels in children with PS as well as in children with OSAS, and supports the underlying inflammation, hence, highlighting the importance of an early diagnosis of this previously considered benign form of SDB.

Indexed as

Mean Platelet VolumeChildC-Reactive ProteinFemaleHumansMaleSleep Apnea, ObstructiveSnoringSyndromeVitamin DC-Reactive ProteinVitamin D

Identifiers

PMID27054959
PMCPMC4824489
OpenAlexW2316055379

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.