Evidence map›Paper›PMID 27054552›Full record

ArticleEndocrinology2016

Sensitization of the Hypothalamic-Pituitary-Adrenal Axis in a Male Rat Chronic Stress Model.

Alier J Franco, Chun Chen, Tyler Scullen, Andrea Zsombok, Ahmed A Salahudeen, Shi Di, James P Herman, Jeffrey G Tasker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024
    Review
  10. Effects of Psychological Stress on Multiple SclerosisCNS & neurological disorders drug targets · 2024
    Review
  11. Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alier J FrancoDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Chun ChenDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Tyler ScullenDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Andrea ZsombokDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Ahmed A SalahudeenDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Shi DiDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
James P HermanDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Jeffrey G TaskerDepartment of Cell and Molecular Biology (A.J.F., C.C., T.S., A.A.S., S.D., J.G.T.) and Neuroscience Program (A.Z., J.G.T.), Tulane University, New Orleans, Louisiana 70118; Departments of Physiology and Medicine (A.Z.), Tulane University Health Sciences Center, New Orleans, Louisiana 70112; and Department of Psychiatry and Behavioral Neuroscience (J.P.H.), University of Cincinnati College of Medicine, Cincinnati, Ohio 45229.
Tulane University · USUniversity of Cincinnati Medical Center · US

Funding

Anatomical Plasticity and HPA Axis DysfunctionR01MH069725 · NIMH · UNIVERSITY OF CINCINNATI · PI HERMAN, JAMES P · 2005 to 2009
$1.9M
Cellular Plasticity and HPA Axis DysfunctionR01MH069879 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI TASKER, JEFFREY G · 2004 to 2009
$1.9M
NIMH NIH HHS R01 MH069725NIMH NIH HHS R01 MH069879
6 · The paper itself

Abstract

Stress activation of the hypothalamic-pituitary-adrenal (HPA) axis is regulated by rapid glucocorticoid negative feedback. Chronic unpredictable stress animal models recapitulate certain aspects of major depression in humans, which have been attributed to impaired glucocorticoid negative feedback. We tested for an attenuated HPA sensitivity to fast glucocorticoid feedback inhibition in male rats exposed to a chronic variable stress (CVS) paradigm. In vitro, parvocellular neuroendocrine cells of the hypothalamic paraventricular nucleus recorded in slices from CVS rats showed an increase in basal excitatory synaptic inputs and a decrease in basal inhibitory synaptic inputs compared with neurons from control rats. There was no difference between control and CVS-treated rats in the rapid glucocorticoid suppression of excitatory synaptic inputs, a fast feedback mechanism. In vivo, CVS-treated rats showed an increase in ACTH secretion at baseline and after both iv CRH and acute stress and no impairment of the corticosterone suppression of the ACTH response, compared with controls. In an in vitro pituitary preparation, an increase in basal ACTH release, a small increase in CRH-induced ACTH release, and no decrement in the glucocorticoid suppression of ACTH release were seen in pituitaries from CVS rats. Thus, CVS does not suppress rapid glucocorticoid negative feedback at the hypothalamus or pituitary, but increases the synaptic excitability of paraventricular nucleus CRH neurons and the CRH sensitivity of the pituitary. Therefore, increased HPA activity in chronically stressed male rats is due to sensitization of the HPA axis, rather than to desensitization to rapid glucocorticoid feedback.

Indexed as

Adrenal GlandsAdrenocorticotropic HormoneAnimalsBody WeightCorticosteroneGlucocorticoidsHypothalamo-Hypophyseal SystemMaleNeuronsPituitary-Adrenal SystemPituitary GlandRatsStress, PhysiologicalAdrenocorticotropic HormoneCorticosteroneGlucocorticoids

Identifiers

PMID27054552
PMCPMC4891782
OpenAlexW2317451733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.