ArticleThe Journal of clinical endocrinology and metabolism2016
Adipose Insulin Resistance in Obese Adolescents Across the Spectrum of Glucose Tolerance.
Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Randomized clinical trial: effect of low-dose flutamide on abdominal adipogenic function in normal-weight women with polycystic ovary syndrome.Fertility and sterility · 2023Trial
- Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance.Journal of diabetes research · 2018Trial
- Comparative effects of exercise modalities on ectopic fat reduction in overweight and obese children and adolescents: a narrative review.European journal of pediatrics · 2026Review
- Organelle-specific crosstalk between calcium and redox signaling in pancreatic β-cells in physiology and type 2 diabetes.Frontiers in network physiology · 2026Review
- Cardio-Metabolic Risk in Adults Born Preterm: A Narrative Review.Journal of clinical medicine · 2025Review
- Metabolic syndrome in children and adolescents: definitions, epidemiology, pathophysiology, interventions, and challenges.Frontiers in endocrinology · 2025Review
- Associations of adipose insulin resistance index with pancreatic β cell function (inverse) and glucose excursion (positive) in young Japanese women.Scientific reports · 2024Article
- Adipose tissue specific insulin resistance and prognosis of nondiabetic patients with ischemic stroke.Diabetology & metabolic syndrome · 2023Article
- An Evolutionary Model for the Ancient Origins of Polycystic Ovary Syndrome.Journal of clinical medicine · 2023Article
- The Level of Inflammatory Markers and Their Relationship with Fat Tissue Distribution in Children with Obesity and Type 2 Diabetes Mellitus.Turkish archives of pediatrics · 2023Article
- Interplay of Cortisol, Testosterone, and Abdominal Fat Mass in Normal-weight Women With Polycystic Ovary Syndrome.Journal of the Endocrine Society · 2023Article
- Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2023Observational
- Cardiometabolic risk factors among children who are affected by overweight, obesity and severe obesity.Frontiers in public health · 2023Article
- Reduced Growth Hormone Predicts Worsening Adipose Tissue Insulin Resistance in Adults with Obesity.Obesity facts · 2023Article
- Expert consensus on the glycemic management of critically ill patients.Journal of intensive medicine · 2022Article
- Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation.Reproductive biology and endocrinology : RB&E · 2022Review
- Autoimmune reaction against pancreatic beta cells in children and adolescents with simple obesity.Frontiers in endocrinology · 2022Observational
- Severe Obesity in Children and Adolescents: Metabolic Effects, Assessment, and Treatment.Journal of obesity & metabolic syndrome · 2021Review
- Effect of aging on clinical features and metabolic complications of women with polycystic ovary syndrome.Journal of endocrinological investigation · 2021Article
- Serum Testosterone to Androstenedione Ratio Predicts Metabolic Health in Normal-Weight Polycystic Ovary Syndrome Women.Journal of the Endocrine Society · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextAdipocytes represent an important insulin-responsive tissue taking an active part in glucose metabolism.
objectiveThis study sought to assess adipose tissue insulin resistance (IR) across the spectrum of glucose tolerance and to test its relation with free fatty acid (FFA) suppression during an oral glucose tolerance test (OGTT). DESIGN AND
settingA cross-sectional analysis of a pediatric clinic-derived cohort of obese adolescents. PATIENTS OR OTHER
participantsParticipants age 7-20 y with a body mass index that exceeded the 95th percentile for their age and sex. INTERVENTION(S): A standard oral glucose tolerance test.
main outcome measuresThe adipose tissue insulin resistance index (calculated as the product of fasting insulin and FFA concentrations) (Adipose IR) and the area under curve of FFAs during the OGTT were compared between glucose tolerance categories.
resultsA total of 962 obese children and adolescents participated in this study. Adipose IR significantly increased across glucose tolerance categories (P for trend < .001). Within the normal glucose tolerance participants, an increase in adipose IR was observed related to an increase in 2-hr glucose levels. In a subsample of participants who underwent abdominal imaging for determination of lipid partitioning (n = 115), a tight relation of visceral fat (r = 0.34; P < .001) and the visceral/sc fat ratio (r = 0.55; P < .001) with the Adipose IR index was evident. Greater area under the curve FFAs (lower FFA suppression) during the OGTT was evident with worsening glucose tolerance (P for trend < .001). Glucose tolerance category, degree of obesity (body mass index-z score), IL-6, and low adiponectin emerged as significant predictors of the Adipose IR.
conclusionsAdipose IR is associated with reduced suppression of FFAs during the OGTT and with an altered adipocytokine profile. The negative relation with insulin secretion deserves further longitudinal investigation in the context of deteriorating glucose tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.