Evidence map›Paper›PMID 27054167›Full record

ArticleData in brief2016

Data describing the swelling behavior and cytocompatibility of biodegradable polyelectrolyte hydrogels incorporating poly(L-lysine) for applications in cartilage tissue engineering.

Johnny Lam, Elisa C Clark, Eliza L S Fong, Esther J Lee, Steven Lu, Yasuhiko Tabata, Antonios G Mikos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johnny LamDepartment of Bioengineering, Rice University, Houston, TX, USA.
Elisa C ClarkDepartment of Bioengineering, Rice University, Houston, TX, USA.
Eliza L S FongDepartment of Bioengineering, Rice University, Houston, TX, USA.
Esther J LeeDepartment of Bioengineering, Rice University, Houston, TX, USA.
Steven LuDepartment of Bioengineering, Rice University, Houston, TX, USA.
Yasuhiko TabataDepartment of Biomaterials, Institute of Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
Antonios G MikosDepartment of Bioengineering, Rice University, Houston, TX, USA.

Funding

Injectable Cellular Composites for Cartilage EngineeringR01AR048756 · NIAMS · RICE UNIVERSITY · PI KASPER, FRED KURTIS, MIKOS, ANTONIOS G. · 2003 to 2014
$3.3M
In Situ Hardening Cell-Laden Constructs for Osteochondral Tissue EngineeringR01AR068073 · NIAMS · RICE UNIVERSITY · PI MIKOS, ANTONIOS G. · 2015 to 2019
$1.7M
NIAMS NIH HHS R01 AR048756NIAMS NIH HHS R01 AR068073
6 · The paper itself

Abstract

This data article presents data associated with the research article entitled "Evaluation of cell-laden polyelectrolyte hydrogels incorporating poly(L-lysine) for applications in cartilage tissue engineering" (Lam et al., 2016) [1]. Synthetic hydrogel composites fabricated using oligo(poly(ethylene glycol) fumarate) (OPF) macromers were utilized as vehicles for the incorporation of poly(L-lysine) (PLL) as well as the encapsulation of mesenchymal stem cells (MSCs). PLL-laden and PLL-free hydrogels were fabricated to characterize the main and interaction effects of OPF molecular weight, PLL molecular weight, and PLL loading density on the swelling and degradation of synthetic OPF hydrogels. Cells were then encapsulated within such hydrogels for in vitro culture and examined for viability, biochemical activity, and chondrogenic gene expression. These data, which are supplementary to the associated research article (Lam et al., 2016) [1], are presented here.

Indexed as

Cartilage tissue engineeringChondrogenic differentiationCondensationHydrogelMesenchymal stem cellsPoly(L-lysine)

Identifiers

PMID27054167
PMCPMC4802419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.