ArticleCell journal2016
Boron Induces Early Matrix Mineralization via Calcium Deposition and Elevation of Alkaline Phosphatase Activity in Differentiated Rat Bone Marrow Mesenchymal Stem Cells.
Article in Cell journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Plant-based macronutrients and micronutrients in combating osteoporosis: research insights and molecular pathways.RSC advances · 2026Review
- Borate-Ion-Stimulated Macrophages Promote Osteogenic Differentiation of Mesenchymal Stem Cells.Advanced healthcare materials · 2026Article
- Evaluation of the remineralisation effect and biocompatibility of boron-doped bioactive glass material on artificial root surface caries.BMC oral health · 2025Article
- Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts.Beilstein journal of nanotechnology · 2025Article
- Low-Mineral Water Diminishes the Bone Benefits of Boron.Nutrients · 2024Article
- Osteogenic Differentiation Capacity of Dental Pulp Stem Cells on 3D Printed Polyurethane/Boric Acid Scaffold.Biological trace element research · 2024Article
- Effects of boric acid on alveolar sockets filling after dental extraction in rats.Oral and maxillofacial surgery · 2024Article
- Investigation of the efficacy of epidermal growth factor, boric acid and their combination in cartilage injury in rats: An experimental study.Joint diseases and related surgery · 2024Article
- Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts.Polymers · 2023Article
- The Localized Ionic Microenvironment in Bone Modelling/Remodelling: A Potential Guide for the Design of Biomaterials for Bone Tissue Engineering.Journal of functional biomaterials · 2023Review
- Article
- Evaluation of the osteogenic effect of apigenin on human mesenchymal stem cells by inhibiting inflammation through modulation of NF-κB/IκBα.Research in pharmaceutical sciences · 2022Article
- Boron-doped Biphasic Hydroxyapatite/β-Tricalcium Phosphate for Bone Tissue Engineering.Biological trace element research · 2021Article
- The Effect of Boron-Containing Nano-Hydroxyapatite on Bone Cells.Biological trace element research · 2020Article
- Boron mediated 2D and 3D cultures of adipose derived mesenchymal stem cells.Cytotechnology · 2019Article
- Water-soluble factors eluated from surface pre-reacted glass-ionomer filler promote osteoblastic differentiation of human mesenchymal stem cells.Molecular medicine reports · 2018Article
- Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway.BioMed research international · 2018Article
- Characterisation of Bone Beneficial Components from Australian Wallaby Bone.Medicines (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBoron (B) is essential for plant development and might be an essential micronutrient for animals and humans. This study was conducted to characterize the impact of boric acid (BA) on the cellular and molecular nature of differentiated rat bone marrow mesenchymal stem cells (BMSCs). MATERIALS AND
methodsIn this experimental study, BMSCs were extracted and expanded to the 3rdpassage, then cultured in Dulbecco's Modified Eagle's Medium (DMEM) complemented with osteogenic media as well as 6 ng/ml and 6 µg/ml of BA. After 5, 10, 15 and 21 days the viability and the level of mineralization was determined using MTT assay and alizarin red respectively. In addition, the morphology, nuclear diameter and cytoplasmic area of the cells were studied with the help of fluorescent dye. The concentration of calcium, activity of alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) as well as sodium and potassium levels were also evaluated using commercial kits and a flame photometer respectively.
resultsAlthough 6 µg/ml of BA was found to be toxic, a concentration of 6 ng/ml increased the osteogenic ability of the cell significantly throughout the treatment. In addition it was observed that B treatment caused the early induction of matrix mineralization compared to controls.
conclusionAlthough more investigation is required, we suggest the prescription of a very low concentration of B in the form of BA or foods containing BA, in groups at high risk of osteoporosis or in the case of bone fracture.
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