Evidence map›Paper›PMID 27054085›Full record

ArticleClinical cancer drugs

Arsenic-exposed Keratinocytes Exhibit Differential microRNAs Expression Profile; Potential Implication of miR-21, miR-200a and miR-141 in Melanoma Pathway.

Horacio Gonzalez, Carolina Lema, Robert A Kirken, Rosa A Maldonado, Armando Varela-Ramirez, Renato J Aguilera

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer drugs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. Epigenomic reprogramming in iAs-mediated carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  4. Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  5. miRNAs and arsenic-induced carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Arsenic-Induced Carcinogenesis: The Impact of miRNA Dysregulation.Toxicological sciences : an official journal of the Society of Toxicology · 2018
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Horacio GonzalezDepartment of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, 500 West University Ave. El Paso, Texas, 79968, USA.
Carolina LemaCytometry, Screening and Imaging Core Facility, Border Biomedical Research Center, Department of Biological Sciences, the University of Texas at El Paso, El Paso, Texas, 79968, USA; College of Optometry, University of Houston, 4901 Calhoun Road, Houston, Texas, 77204, USA.
Robert A KirkenDepartment of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, 500 West University Ave. El Paso, Texas, 79968, USA.
Rosa A MaldonadoDepartment of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, 500 West University Ave. El Paso, Texas, 79968, USA.
Armando Varela-RamirezDepartment of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, 500 West University Ave. El Paso, Texas, 79968, USA; Cytometry, Screening and Imaging Core Facility, Border Biomedical Research Center, Department of Biological Sciences, the University of Texas at El Paso, El Paso, Texas, 79968, USA.
Renato J AguileraDepartment of Biological Sciences, Border Biomedical Research Center, the University of Texas at El Paso, 500 West University Ave. El Paso, Texas, 79968, USA; Cytometry, Screening and Imaging Core Facility, Border Biomedical Research Center, Department of Biological Sciences, the University of Texas at El Paso, El Paso, Texas, 79968, USA.
The University of Texas at El Paso · US

Funding

TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
RISE Scholars Program at UTEPR25GM069621 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2004 to 2021
$11.2M
Characterization of novel compounds with anti-lymphoma activitySC3GM103713 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2013 to 2016
$453k
NIGMS NIH HHS R25 GM069621NIGMS NIH HHS SC3 GM103713NIMHD NIH HHS G12 MD007592
6 · The paper itself

Abstract

Long-term exposure to arsenic has been linked to cancer in different organs and tissues, including skin. Here, non-malignant human keratinocytes (HaCaT) were exposed to arsenic and its effects on microRNAs (miRNAs; miR) expression were analyzed

Indexed as

ArsenitecancercarcinogenesismiR-141miR-200amiR-21miRNA-based cancer therapyskin cancer

Identifiers

PMID27054085
PMCPMC4819983
OpenAlexW2415435465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.