Evidence map›Paper›PMID 27054074›Full record

ArticleApplied & translational genomics2015

OncDRS: An integrative clinical and genomic data platform for enabling translational research and precision medicine.

John Orechia, Ameet Pathak, Yunling Shi, Aniket Nawani, Andrey Belozerov, Caitlin Fontes, Camille Lakhiani, Chetan Jawale, Chetansharan Patel, Daniel Quinn and 12 more

Open access · hybridAbstract read
In one paragraph

Article in Applied & translational genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

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  11. Glioma genetic profiles associated with electrophysiologic hyperexcitability.medRxiv : the preprint server for health sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 1 institution in 1 country.

John OrechiaDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Ameet PathakDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Yunling ShiDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Aniket NawaniDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Andrey BelozerovDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Caitlin FontesDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Camille LakhianiDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Chetan JawaleDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Chetansharan PatelDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Daniel QuinnDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Dmitry BotvinnikDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Eddie MeiDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Elizabeth CotterDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
James ByleckieDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Mollie Ullman-CullereDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Padam ChhetriDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Poornima ChalasaniDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Purushotham KarnamDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Ronald BeaudoinDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Sandeep SahuDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Yelena BelozerovaDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Jomol P MathewDana-Faber Cancer Institute, 450 Brookline Ave., Boston, MA-02215, United States.
Dana-Farber Cancer Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We live in the genomic era of medicine, where a patient's genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS) and a suite of tools called Oncology Data Retrieval Systems (OncDRS). OncDRS enables seamless data integration, secure and self-navigated query and extraction of clinical and genomic data from heterogeneous sources. Within a year of release, the system has facilitated more than 1500 research queries and has delivered data for more than 50 research studies.

Indexed as

Clinical and translational informaticsClinical & genomic data integrationGenomic profileNext generation sequencing dataPrecision medicine

Identifiers

PMID27054074
PMCPMC4803771
OpenAlexW1819859586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.