ArticleInternational journal for parasitology. Drugs and drug resistance2016
Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil.
Article in International journal for parasitology. Drugs and drug resistance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- Pharmacokinetic and Pharmacodynamic Assessments of the Ivermectin and Levamisole Combination to Control Resistant Nematodes in Cattle.Pharmaceutics · 2026Article
- Variability in the anthelmintic efficacy of levamisole against gastrointestinal nematodes of cattle, sheep and goats in South Darfur, Sudan.BMC veterinary research · 2026Article
- Role of Silver Nanoparticles for the Control of Anthelmintic Resistance in Small and Large Ruminants.Biological trace element research · 2024Review
- Article
- Anthelmintic resistance of gastrointestinal nematodes in cattle in Brazil and Argentina - current status and global perspectives.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2024Review
- Integration of ITS-2 rDNA nemabiome metabarcoding with Fecal Egg Count Reduction Testing (FECRT) reveals ivermectin resistance in multiple gastrointestinal nematode species, including hypobiotic Ostertagia ostertagi, in western Canadian beef cattle.International journal for parasitology. Drugs and drug resistance · 2023Article
- Benzimidazole Resistance in Cattle: The First Report of the Presence of F200Y Mutation inVeterinary sciences · 2023Article
- The Economic Impact of Parasitism from Nematodes, Trematodes and Ticks on Beef Cattle Production.Animals : an open access journal from MDPI · 2023Review
- Trapping Behaviour ofPathogens (Basel, Switzerland) · 2023Article
- Variability in the Response againstInternational journal of molecular sciences · 2022Article
- Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance.International journal for parasitology. Drugs and drug resistance · 2020Article
- The threat of reduced efficacy of anthelmintics against gastrointestinal nematodes in sheep from an area considered anthelmintic resistance-free.Parasites & vectors · 2020Article
- Article
- Economic losses caused by the use of low-efficacy anthelmintic drugs in growing heifers.Tropical animal health and production · 2020Article
- Effects of cholesterol content on activity of P-glycoproteins and membrane physical state, and consequences for anthelmintic resistance in the nematode Haemonchus contortus.Parasite (Paris, France) · 2020Article
- Anthelmintic Activity of Extracts and Active Compounds FromFrontiers in veterinary science · 2020Article
- Molecular detection of two major gastrointestinal parasite genera in cattle using a novel droplet digital PCR approach.Parasitology research · 2019Article
- Article
- Economic viability of anthelmintic treatment in naturally infected beef cattle under different nutritional strategies after weaning.Parasitology research · 2018Article
- Immunity to gastrointestinal nematodes in ruminants: effector cell mechanisms and cytokines.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal nematodes resistant to anthelmintics have been reported in several regions of Brazil, and they may be associated with economic losses for the cattle industry. This study aimed to evaluate the resistance status of gastrointestinal nematodes from naturally infected beef cattle to several commercially available anthelmintics, as well as to test the efficacy of combinations of anthelmintics against multi-resistant gastrointestinal nematodes. Ten farms located in Rio Grande do Sul state were selected by: farmers' consent; extensive raising system; availability of calves aged from 7 to 9 months naturally infected by gastrointestinal nematodes; absence of anthelmintic treatment for 60 days before the study; and presence of 70-100 calves or more of both genders with ≥ 200 eggs per gram of feces (EPG) (sensitivity of 50 EPG). These calves were distributed into 10 groups (of 7-10 animals) per farm and treated with ivermectin, doramectin, eprinomectin, fenbendazole, closantel, nitroxynil, disophenol, levamisole, albendazole, or moxidectin. Feces were collected 2 days before treatment and 14 days after treatment. Additional groups of 7-10 calves were used to test six different two-drug combinations at four of the studied farms. In general terms, fenbendazole was the most effective drug, followed by levamisole, disophenol, and moxidectin. However, parasite resistance to multiple drugs was found in all herds, especially in the genera Cooperia spp., Trichostrongylus spp., and Haemonchus spp.. Some of the two-drug combinations were effective against nematode populations identified as resistant to the same compounds when used as single drugs. The most effective combinations were moxidectin + levamisole, doramectin + fenbendazole, and levamisole + closantel. In this study, parasites resistant to the main commercially available anthelmintics were found in all herds, and some combinations of two active components belonging to different chemical groups were effective against multi-drug resistant gastrointestinal nematodes.
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