Evidence map›Paper›PMID 27053974›Full record

ArticleThe annals of applied statistics2015

ASSESSING PHENOTYPIC CORRELATION THROUGH THE MULTIVARIATE PHYLOGENETIC LATENT LIABILITY MODEL.

Gabriela B Cybis, Janet S Sinsheimer, Trevor Bedford, Alison E Mather, Philippe Lemey, Marc A Suchard

Open access · greenAbstract read
In one paragraph

Article in The annals of applied statistics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
12.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Leveraging graphical model techniques to study evolution on phylogenetic networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  6. Article
  7. Article
  8. Data integration in Bayesian phylogenetics.Annual review of statistics and its application · 2023
    Article
  9. Article
  10. Statistical Challenges in Tracking the Evolution of SARS-CoV-2.Statistical science : a review journal of the Institute of Mathematical Statistics · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Relaxed Random Walks at Scale.Systematic biology · 2021
    Article
  15. Massive parallelization boosts big Bayesian multidimensional scaling.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2021
    Article
  16. On the Matrix Condition of Phylogenetic Tree.Evolutionary bioinformatics online · 2020
    Article
  17. Phylogenetic Factor Analysis.Systematic biology · 2018
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Gabriela B CybisFederal University of Rio Grande do Sul.
Janet S SinsheimerUniversity of California, Los Angeles.
Trevor BedfordFred Hutchinson Cancer Research Center.
Alison E MatherWellcome Trust Sanger Institute.
Philippe LemeyKU Leuven.
Marc A SuchardUniversity of California, Los Angeles.
University of California, Los Angeles · USFred Hutch Cancer Center · USKU Leuven · BEUniversity of Rio Grande and Rio Grande Community College · USWellcome Sanger Institute · GB

Funding

Genomics, GPUs, and Next Generation Computational StatisticsR01HG006139 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOBEL, ERIC · 2011 to 2023
$5.1M
BAYESIAN MODELING AND DATA INTEGRATION IN INFECTIOUS DISEASE PHYLODYNAMICSR01AI107034 · NIAID · UNIVERSITY OF WASHINGTON · PI MININ, VOLODYMYR · 2013 to 2017
$1.7M
European Research Council 260864NHGRI NIH HHS R01 HG006139NIAID NIH HHS R01 AI107034Wellcome Trust
6 · The paper itself

Abstract

Understanding which phenotypic traits are consistently correlated throughout evolution is a highly pertinent problem in modern evolutionary biology. Here, we propose a multivariate phylogenetic latent liability model for assessing the correlation between multiple types of data, while simultaneously controlling for their unknown shared evolutionary history informed through molecular sequences. The latent formulation enables us to consider in a single model combinations of continuous traits, discrete binary traits, and discrete traits with multiple ordered and unordered states. Previous approaches have entertained a single data type generally along a fixed history, precluding estimation of correlation between traits and ignoring uncertainty in the history. We implement our model in a Bayesian phylogenetic framework, and discuss inference techniques for hypothesis testing. Finally, we showcase the method through applications to columbine flower morphology, antibiotic resistance in

Indexed as

Bayesian phylogeneticsEvolutionGenotype-phenotype correlationThreshold model

Identifiers

PMID27053974
PMCPMC4820077
OpenAlexW2124842723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.