ReviewImmunity & ageing : I & A2016
Human longevity: Genetics or Lifestyle? It takes two to tango.
Review in Immunity & ageing : I & A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Comparison of life expectancy determinants among gulf cooperation council members.BMC public health · 2025Pooled it
- A systematic review of diet and medication use among centenarians and near-centenarians worldwide.GeroScience · 2024Pooled it
- Gut Microbiota and Ageing: Mechanisms, Age-Related Diseases, and Therapeutic Perspectives.Healthcare (Basel, Switzerland) · 2026Review
- Systems and Molecular Biology of Longevity and Preventive Medicine: Brain-Energy-Microbiome-Exposome Synergies in Blue Zones and the Cilento Case.International journal of molecular sciences · 2025Review
- Translational fidelity and longevity are genetically linked.Nature communications · 2025Article
- German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway.GeroScience · 2025Article
- Public Awareness and Perceptions of Longevity Determinants in Saudi Arabia: A Cross-Sectional Study (2024-2025).Healthcare (Basel, Switzerland) · 2025Article
- Unveiling the Anti-Aging Potential of Marine Natural Bioproducts.Marine drugs · 2025Review
- Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.Nature communications · 2025Article
- Discovering the direct relations between nutrients and epigenetic ageing.The journal of nutrition, health & aging · 2024Article
- Definitions of Ageing According to the Perspective of the Psychology of Ageing: A Scoping Review.Geriatrics (Basel, Switzerland) · 2024Article
- Genetic associations with human longevity are enriched for oncogenic genes.medRxiv : the preprint server for health sciences · 2024Article
- Assessment of Dietary and Lifestyle Quality among the Romanian Population in the Post-Pandemic Period.Healthcare (Basel, Switzerland) · 2024Article
- Comparative analysis of animal lifespan.GeroScience · 2024Review
- Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity.Frontiers in aging · 2024Review
- Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics.Redox biology · 2023Review
- Essentials to Improve the Effectiveness of Healthy Aging Programming: Consideration of Social Determinants and Utilization of a Theoretical Model.International journal of environmental research and public health · 2023Article
- Prevalence of family history of cancer in the NC-CCAPH consortium of Japan.Scientific reports · 2023Article
- Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.The Journal of clinical investigation · 2023Article
- Adherence to cognitive and physical exercise engagement: a challenge to successful dementia risk reduction and prevention efforts.Frontiers in dementia · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic factors. The search for genetic and molecular basis of aging has led to the identification of genes correlated with the maintenance of the cell and of its basic metabolism as the main genetic factors affecting the individual variation of the aging phenotype. In addition, studies on calorie restriction and on the variability of genes associated with nutrient-sensing signaling, have shown that ipocaloric diet and/or a genetically efficient metabolism of nutrients, can modulate lifespan by promoting an efficient maintenance of the cell and of the organism. Recently, epigenetic studies have shown that epigenetic modifications, modulated by both genetic background and lifestyle, are very sensitive to the aging process and can either be a biomarker of the quality of aging or influence the rate and the quality of aging. On the whole, current studies are showing that interventions modulating the interaction between genetic background and environment is essential to determine the individual chance to attain longevity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.