Evidence map›Paper›PMID 27053856›Full record

ArticleWorld journal of gastroenterology2016

Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study.

Quirijn R J G Tummers, Leonora S F Boogerd, Wobbe O de Steur, Floris P R Verbeek, Martin C Boonstra, Henricus J M Handgraaf, John V Frangioni, Cornelis J H van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer

Open access · hybridAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  17. Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Quirijn R J G TummersQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Leonora S F BoogerdQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Wobbe O de SteurQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Floris P R VerbeekQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Martin C BoonstraQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Henricus J M HandgraafQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
John V FrangioniQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Cornelis J H van de VeldeQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Henk H HartgrinkQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Alexander L VahrmeijerQuirijn RJG Tummers, Leonora SF Boogerd, Wobbe O de Steur, Floris PR Verbeek, Martin C Boonstra, Henricus JM Handgraaf, Cornelis JH van de Velde, Henk H Hartgrink, Alexander L Vahrmeijer, Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Hadassah Medical Center · ILBeth Israel Deaconess Medical Center · USLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate feasibility and accuracy of near-infrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node (SLN) detection in gastric cancer.

methodsA prospective, single-institution, phase I feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 mL ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE™ NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.

resultsTwenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging (mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90% (70%-99%; 95%CI), which decreased by higher pT-stage (100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4 (range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.

conclusionThis study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified.

Indexed as

Spectroscopy, Near-InfraredAdultAgedAged, 80 and overFeasibility StudiesFemaleFluorescent DyesGastrectomyHumansIndocyanine GreenLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedNetherlandsFluorescent DyesIndocyanine GreenGastric cancerImage-guided surgeryIndocyanine greenNear-infrared fluorescence imagingSentinel lymph node

Identifiers

PMID27053856
PMCPMC4814650
OpenAlexW2312341791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.