Trial reportSocial cognitive and affective neuroscience2016
Oxytocin, but not vasopressin, impairs social cognitive ability among individuals with higher levels of social anxiety: a randomized controlled trial.
Trial report in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01680718 (Neuropeptides and Social Behavior), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuropeptides and Social Behavior
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial.Psychological medicine · 2023Trial
- Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial.Psychoneuroendocrinology · 2019Trial
- Intranasal oxytocin modulates higher order social cognition in body dysmorphic disorder.Depression and anxiety · 2019Trial
- Electrophysiological correlates of oxytocin-induced enhancement of social performance monitoring.Social cognitive and affective neuroscience · 2017Trial
- Social Working Memory: a Systematic Review.Neuropsychology review · 2026Review
- General and Specific Facets of Anxiety: Psychometric Analysis and Impact on Cognitive Performance.Behavioral sciences (Basel, Switzerland) · 2026Article
- A role for theThe American journal of drug and alcohol abuse · 2020Article
- Epigenetic regulation of the oxytocin receptor is associated with neural response during selective social attention.Translational psychiatry · 2018Article
- Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward.Neuroscience and biobehavioral reviews · 2017Review
- Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects.Current psychiatry reports · 2017Review
- Oxytocin Increases the Perceived Value of Both Self- and Other-Owned Items and Alters Medial Prefrontal Cortex Activity in an Endowment Task.Frontiers in human neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with social anxiety are characterized by a high degree of social sensitivity, which can coincide with impairments in social cognitive functioning (e.g. theory of mind). Oxytocin (OT) and vasopressin (AVP) have been shown to improve social cognition, and OT has been theorized as a potential therapeutic agent for individuals with social anxiety disorder. However, no study has investigated whether these neuropeptides improve social cognitive ability among socially anxious individuals. In a randomized, double-blind, placebo controlled, between-subjects design we investigated whether social anxiety moderated the effects of OT or AVP (vs placebo) on social working memory (i.e. working memory that involves manipulating social information) and non-social working memory. OT vs placebo impaired social working memory accuracy in participants with higher levels of social anxiety. No differences were found for non-social working memory or for AVP vs placebo. Results suggest that OT administration in individuals with higher levels of social anxiety may impair social cognitive functioning. Randomized-controlled trial registration: NCT01680718.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.