Evidence map›Paper›PMID 27053677›Full record

ArticleJournal of clinical microbiology2016

In Vitro Comparison of Ertapenem, Meropenem, and Imipenem against Isolates of Rapidly Growing Mycobacteria and Nocardia by Use of Broth Microdilution and Etest.

Barbara A Brown-Elliott, Jessica Killingley, Sruthi Vasireddy, Linda Bridge, Richard J Wallace

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

  1. Nocardia antimicrobial susceptibility testing by microdilution: evaluation of ready-to-use plate including tedizolid and meropenem.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Article
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  4. Description and complete genome sequence ofFrontiers in microbiology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Prosthetic joint infection caused by an imipenem-resistant Mycobacterium senegalense.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  9. Article
  10. Updated Review onClinical microbiology reviews · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Multiple brain abscesses due to Nocardia spp. in an immunocompetent patientBiomedica : revista del Instituto Nacional de Salud · 2020
    Article
  16. Assessment of VITEK® MS IVD database V3.0 for identification of Nocardia spp. using two culture media and comparing direct smear and protein extraction procedures.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Barbara A Brown-ElliottThe University of Texas Health Science Center, Tyler, Texas, USA.
Jessica KillingleyThe University of Texas Health Science Center, Tyler, Texas, USA.
Sruthi VasireddyThe University of Texas Health Science Center, Tyler, Texas, USA.
Linda BridgeThe University of Texas Health Science Center, Tyler, Texas, USA.
Richard J WallaceThe University of Texas Health Science Center, Tyler, Texas, USA richard.wallace@uthct.edu.
The University of Texas Health Science Center at Tyler · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the activities of the carbapenems ertapenem, meropenem, and imipenem against 180 isolates of rapidly growing mycobacteria (RGM) and 170 isolates of Nocardia using the Clinical and Laboratory Standards Institute (CLSI) guidelines. A subset of isolates was tested using the Etest. The rate of susceptibility to ertapenem and meropenem was limited and less than that to imipenem for the RGM. Analysis of major and minor discrepancies revealed that >90% of the isolates of Nocardia had higher MICs by the broth microdilution method than by Etest, in contrast to the lower broth microdilution MICs seen for >80% of the RGM. Imipenem remains the most active carbapenem against RGM, including Mycobacterium abscessus subsp. abscessus For Nocardia, imipenem was significantly more active only against Nocardia farcinica Although there may be utility in testing the activities of the newer carbapenems against Nocardia, their activities against the RGM should not be routinely tested. Testing by Etest is not recommended by the CLSI.

Indexed as

Anti-Bacterial Agentsbeta-LactamsErtapenemHumansImipenemMeropenemMicrobial Sensitivity TestsNocardiaNontuberculous MycobacteriaThienamycinsAnti-Bacterial Agentsbeta-LactamsErtapenemImipenemMeropenemThienamycins

Identifiers

PMID27053677
PMCPMC4879266
OpenAlexW2331807069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.