ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Impacts of Climate Change and Related Weather Events on the Health and Wellbeing of Culturally and Linguistically Diverse Communities: A Systematic Review.Journal of racial and ethnic health disparities · 2026Pooled it
- Environmental risk factors for chronic kidney disease of non-traditional causes in tropical coastal areas: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities.Military Medical Research · 2023Pooled it
- Ambient temperature, humidity, and urinary system diseases: a population-based study in Western China.Environmental science and pollution research international · 2022Pooled it
- Hydrating with a higher-fructose sport drink does not worsen acute kidney injury risk during simulated work-related heat stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Trial
- Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.BMC nephrology · 2018Trial
- Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study.PloS one · 2017Trial
- Experiences of heat stress and adapting practices among farmworkers in northwest Nicaragua: a qualitative study.BMJ open · 2026Article
- Oxidative Stress in Heat Stress Nephropathy: Crosstalk.Oxidative medicine and cellular longevity · 2026Review
- Article
- Machine learning prediction and SHAP interpretability analysis of heart failure risk in patients with hyperuricemia.Frontiers in cardiovascular medicine · 2025Article
- Hydration behaviors, knowledge, and attitudes among Chinese recreational marathon runners: a cross-sectional study.Frontiers in nutrition · 2025Article
- Impact of Fructose-Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats.BioMed research international · 2025Article
- Longitudinal Renal Function Degradation Among Florida Agricultural Workers.Journal of occupational and environmental medicine · 2024Article
- A study on the early metabolic effects of salt and fructose consumption: the protective role of water.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Effect of Glycemic Disorders and Habits on the Concentration of Selected Neurotrophic Factors in Patients with Lumbosacral Intervertebral Disc Degeneration.Current pharmaceutical biotechnology · 2024Article
- Acute kidney injury biomarkers and hydration assessments following prolonged mild hypohydration in healthy young adults.American journal of physiology. Renal physiology · 2023Article
- Fructose: A New Variable to Consider in SIADH and the Hyponatremia Associated With Long-Distance Running?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- Climate change and nephrology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Predicting autosomal dominant polycystic kidney disease progression: review of promising Serum and urine biomarkers.Frontiers in pediatrics · 2023Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Recurrent dehydration, such as commonly occurs with manual labor in tropical environments, has been recently shown to result in chronic kidney injury, likely through the effects of hyperosmolarity to activate both vasopressin and aldose reductase-fructokinase pathways. The observation that the latter pathway can be directly engaged by simple sugars (glucose and fructose) leads to the hypothesis that soft drinks (which contain these sugars) might worsen rather than benefit dehydration associated kidney disease. Recurrent dehydration was induced in rats by exposure to heat (36°C) for 1 h/24 h followed by access for 2 h to plain water (W), a 11% fructose-glucose solution (FG, same composition as typical soft drinks), or water sweetened with noncaloric stevia (ST). After 4 wk plasma and urine samples were collected, and kidneys were examined for oxidative stress, inflammation, and injury. Recurrent heat-induced dehydration with ad libitum water repletion resulted in plasma and urinary hyperosmolarity with stimulation of the vasopressin (copeptin) levels and resulted in mild tubular injury and renal oxidative stress. Rehydration with 11% FG solution, despite larger total fluid intake, resulted in greater dehydration (higher osmolarity and copeptin levels) and worse renal injury, with activation of aldose reductase and fructokinase, whereas rehydration with stevia water had opposite effects. In animals that are dehydrated, rehydration acutely with soft drinks worsens dehydration and exacerbates dehydration associated renal damage. These studies emphasize the danger of drinking soft drink-like beverages as an attempt to rehydrate following dehydration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.