Evidence map›Paper›PMID 27053629›Full record

ArticleClinical and vaccine immunology : CVI2016

Tetanus Immunity among Women Aged 15 to 39 Years in Cambodia: a National Population-Based Serosurvey, 2012.

Heather M Scobie, Bunsoth Mao, Sokhal Buth, Kathleen A Wannemuehler, Charlotte Sørensen, Chheng Kannarath, M Harley Jenks, Delynn M Moss, Jeffrey W Priest, Sann Chan Soeung and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Heather M ScobieGlobal Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA hscobie@cdc.gov.
Bunsoth MaoUniversity of Health Sciences, Phnom Penh, Cambodia.
Sokhal ButhNational Institute of Public Health, Phnom Penh, Cambodia.
Kathleen A WannemuehlerGlobal Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Charlotte SørensenStatens Serum Institut, Copenhagen, Denmark.
Chheng KannarathNational Institute of Public Health, Phnom Penh, Cambodia.
M Harley JenksDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Delynn M MossDivision of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jeffrey W PriestDivision of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sann Chan SoeungNational Immunization Program, Ministry of Health, Phnom Penh, Cambodia.
Michael S DemingDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Patrick J LammieDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Christopher J GregoryGlobal Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USDivision of Parasitic Diseases and Malaria · USNational Institute of Public Health · KHMinistry of Health · KHStatens Serum Institut · DKUniversity of Health Science · KHWaterborne Environmental (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To monitor progress toward maternal and neonatal tetanus elimination (MNTE) in Cambodia, we conducted a nationwide serosurvey of tetanus immunity in 2012. Multistage cluster sampling was used to select 2,154 women aged 15 to 39 years. Tetanus toxoid antibodies in serum samples were measured by gold-standard double-antigen enzyme-linked immunosorbent assay (DAE) and a novel multiplex bead assay (MBA). Antibody concentrations of ≥0.01 IU/ml by DAE or the equivalent for MBA were considered seroprotective. Estimated tetanus seroprotection was 88% (95% confidence interval [CI], 86 to 89%); 64% (95% CI, 61 to 67%) of women had antibody levels of ≥1.0 IU/ml. Seroprotection was significantly lower (P < 0.001) among women aged 15 to 19 years (63%) and 20 to 24 years (87%) than among those aged ≥25 years (96%), among nulliparous women than among parous women (71 versus 97%), and among those living in the western region than among those living in other regions (82 versus 89%). The MBA showed high sensitivity (99% [95% CI, 98 to 99%]) and specificity (92% [95% CI, 88 to 95%]) compared with DAE. Findings were compatible with MNTE in Cambodia (≥80% protection). Tetanus immunity gaps should be addressed through strengthened routine immunization and targeted vaccination campaigns. Incorporating tetanus testing in national serosurveys using MBAs, which can measure immunity to multiple pathogens simultaneously, may be beneficial for monitoring MNTE.

Indexed as

AdolescentAdultAntibodies, BacterialAntitoxinsCambodiaFemaleHumansImmunoassayTetanusYoung AdultAntibodies, BacterialAntitoxins

Identifiers

PMID27053629
PMCPMC4933773
OpenAlexW2334530722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.