Evidence map›Paper›PMID 27053570›Full record

ArticleComparative medicine2016

Cercopithecine Herpesvirus 9 (Simian Varicella Virus) Infection after Total-Body Irradiation in a Rhesus Macaque (Macaca mulatta).

Jatinder Gulani, Amory Koch, Mark G Chappell, Christine L Christensen, Paul Facemire, Vijay K Singh, Natalia I Ossetrova, Venkataraman Srinivasan, Rebecca K Holt

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Coinfection ofVeterinary world · 2021
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jatinder GulaniVeterinary Science Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Amory KochVeterinary Science Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA.
Mark G ChappellVeterinary Science Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA.
Christine L ChristensenVeterinary Science Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA.
Paul FacemireGlobal Health Engagements, Office of the Surgeon General, Falls Church, Virginia, USA.
Vijay K SinghScientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA; Department of Radiation Biology, F Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Natalia I OssetrovaScientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA.
Venkataraman SrinivasanScientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA.
Rebecca K HoltVeterinary Science Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, USA.
Armed Forces Institute of Pathology · USHenry M. Jackson Foundation · USUniformed Services University of the Health Sciences · USVirginia Department of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report describes a rhesus macaque (Macaca mulatta; male; age, 5 y; weight, 6.7 kg) with anorexia, dehydration, lethargy, ataxia, and generalized skin rashes that occurred 30 d after total-body irradiation at 6.5 Gy ((60)Co γ-rays). Physical examination revealed pale mucus membranes, a capillary refill time of 4 s, heart rate of 180 bpm. and respirations at 50 breaths per minute. Diffuse multifocal maculopapulovesicular rashes were present on the body, including mucocutaneous junctions. The CBC analysis revealed a Hct of 48%, RBC count of 6.2 × 10(6)/μL, platelet count of 44 × 10(3)/μL, and WBC count of 25 × 10(3)/μL of WBC. The macaque was euthanized in light of a grave prognosis. Gross examination revealed white foci on the liver, multifocal generalized petechiation on serosal and mucosal surfaces of the gastrointestinal tract, hemorrhagic lymph nodes, and hemorrhagic fluid in the thoracic cavity. Microscopic examination revealed cutaneous vesicular lesions with intranuclear eosinophilic viral inclusions within the epithelial cells, consistent with herpesvirus. Immunohistochemistry was positive for herpesvirus. The serum sample was negative for antibodies against Macacine herpesvirus 1 and Cercopithecine herpesvirus 9 (simian varicella virus, SVV). Samples submitted for PCR-based identification of the etiologic agent confirmed the presence of SVV DNA. PCR analysis, immunohistochemistry, and histology confirmed that lesions were attributed to an active SVV infection in this macaque. This case illustrates the importance of screening for SVV in rhesus macaques, especially those used in studies that involve immunosuppressive procedures.

Indexed as

Macaca mulattaAnimalsHerpesviridae InfectionsHerpesvirus 1, CercopithecineImmunohistochemistryMaleMonkey DiseasesWhole-Body Irradiation

Identifiers

PMID27053570
PMCPMC4825965
OpenAlexW2336941429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.