Observational studyThe American journal of clinical nutrition2016
Abdominal adipose tissue compartments vary with ethnicity in Asian neonates: Growing Up in Singapore Toward Healthy Outcomes birth cohort study.
Observational study in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174875 (Developmental Pathways to Health and Disease), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood.BMC medicine · 2025Article
- Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood.International journal of epidemiology · 2023Article
- Roadmap for an imaging and modelling paediatric study in rural NZ.Frontiers in physiology · 2023Article
- The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.The Journal of clinical endocrinology and metabolism · 2022Article
- Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution.International journal of obesity (2005) · 2022Article
- Association of increased abdominal adiposity at birth with altered ventral caudate microstructure.International journal of obesity (2005) · 2021Article
- The longitudinal association between early-life screen viewing and abdominal adiposity-findings from a multiethnic birth cohort study.International journal of obesity (2005) · 2021Article
- Automated Segmentation of Visceral, Deep Subcutaneous, and Superficial Subcutaneous Adipose Tissue Volumes in MRI of Neonates and Young Children.Radiology. Artificial intelligence · 2021Article
- Improvements in cholesterol efflux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatric surgery in a cohort with morbid obesity.Diabetology & metabolic syndrome · 2021Article
- Neonatal amygdala microstructure mediates the relationship between gestational glycemia and offspring adiposity.BMJ open diabetes research & care · 2021Article
- Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study.The American journal of clinical nutrition · 2020Article
- Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort.International journal of epidemiology · 2019Article
- Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent.Obesity (Silver Spring, Md.) · 2019Article
- Lifestyle of women before pregnancy and the risk of offspring obesity during childhood through early adulthood.International journal of obesity (2005) · 2018Article
- Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity.International journal of obesity (2005) · 2018Article
- Which anthropometric measures best reflect neonatal adiposity?International journal of obesity (2005) · 2018Article
- Adherence to a healthy eating index for pregnant women is associated with lower neonatal adiposity in a multiethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) Study.The American journal of clinical nutrition · 2018Article
- Maternal plasma phosphatidylcholine polyunsaturated fatty acids during pregnancy and offspring growth and adiposity.Prostaglandins, leukotrienes, and essential fatty acids · 2017Article
- Influence of maternal obesity on the long-term health of offspring.The lancet. Diabetes & endocrinology · 2017Review
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundA susceptibility to metabolic diseases is associated with abdominal adipose tissue distribution and varies between ethnic groups. The distribution of abdominal adipose tissue at birth may give insights into whether ethnicity-associated variations in metabolic risk originate partly in utero.
objectiveWe assessed the influence of ethnicity on abdominal adipose tissue compartments in Asian neonates in the Growing Up in Singapore Toward Healthy Outcomes mother-offspring cohort.
designMRI was performed at ≤2 wk after birth in 333 neonates born at ≥34 wk of gestation and with birth weights ≥2000 g. Abdominal superficial subcutaneous tissue (sSAT), deep subcutaneous tissue (dSAT), and internal adipose tissue (IAT) compartment volumes (absolute and as a percentage of the total abdominal volume) were quantified.
resultsIn multivariate analyses that were controlled for sex, age, and parity, the absolute and percentage of dSAT and the percentage of sSAT (but not absolute sSAT) were greater, whereas absolute IAT (but not the percentage of IAT) was lower, in Indian neonates than in Chinese neonates. Compared with Chinese neonates, Malay neonates had greater percentages of sSAT and dSAT but similar percentages of IAT. Marginal structural model analyses largely confirmed the results on the basis of volume percentages with controlled direct effects of ethnicity on abdominal adipose tissue; dSAT was significantly greater (1.45 mL; 95% CI: 0.49, 2.41 mL, P = 0.003) in non-Chinese (Indian or Malay) neonates than in Chinese neonates. However, ethnic differences in sSAT and IAT were NS [3.06 mL (95% CI:-0.27, 6.39 mL; P = 0.0712) for sSAT and -1.30 mL (95% CI: -2.64, 0.04 mL; P = 0.057) for IAT in non-Chinese compared with Chinese neonates, respectively].
conclusionsIndian and Malay neonates have a greater dSAT volume than do Chinese neonates. This finding supports the notion that in utero influences may contribute to higher cardiometabolic risk observed in Indian and Malay persons in our population. If such differences persist in the longitudinal tracking of adipose tissue growth, these differences may contribute to the ethnic disparities in risks of cardiometabolic diseases. This trial was registered at clinicaltrials.gov as NCT01174875.
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