ArticlePhysiological reports2016
Multiple sites of adaptation lead to contrast encoding in the Drosophila olfactory system.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
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- Manifold learning for olfactory habituation to strongly fluctuating backgrounds.bioRxiv : the preprint server for biology · 2025Article
- Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- A vector-based strategy for olfactory navigation inbioRxiv : the preprint server for biology · 2025Article
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
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- Odor response adaptation in Drosophila-a continuous individualization process.Cell and tissue research · 2021Article
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- Stochastic and Arbitrarily Generated Input Patterns to the Mushroom Bodies Can Serve as Conditioned Stimuli inFrontiers in physiology · 2020Article
- Controlling and measuring dynamic odorant stimuli in the laboratory.The Journal of experimental biology · 2019Article
- Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding.eLife · 2019Article
- Article
- Segregation of Unknown Odors From Mixtures Based on Stimulus Onset Asynchrony in Honey Bees.Frontiers in behavioral neuroscience · 2019Article
- Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies.eLife · 2018Article
- Fast intensity adaptation enhances the encoding of sound in Drosophila.Nature communications · 2018Article
- History-Dependent Odor Processing in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Abstract
Animals often encounter large increases in odor intensity that can persist for many seconds. These increases in the background odor are often accompanied by increases in the variance of the odor stimulus. Previous studies have shown that a persistent odor stimulus (odor background) results in a decrease in the response to brief odor pulses in the olfactory receptor neurons (ORNs). However, the contribution of adapting mechanisms beyond theORNs is not clear. Thus, it is unclear how adaptive mechanisms are distributed within the olfactory circuit and what impact downstream adaptation may have on the encoding of odor stimuli. In this study, adaptation to the same odor stimulus is examined at multiple levels in the well studied and accessibleDrosophilaolfactory system. The responses of theORNs are compared to the responses of the second order, projection neurons (PNs), directly connected to them. Adaptation inPNspike rate was found to be much greater than adaptation in theORNspike rate. This greater adaptation allowsPNs to encode odor contrast (ratio of pulse intensity to background intensity) with little ambiguity. Moreover, distinct neural mechanisms contribute to different aspects of adaptation; adaptation to the background odor is dominated by adaptation in spike generation in bothORNs andPNs, while adaptation to the odor pulse is dominated by changes within olfactory transduction and the glomerulus. These observations suggest that the olfactory system adapts at multiple sites to better match its response gain to stimulus statistics.
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