Trial reportJournal of diabetes science and technology2016
An On-Chip Disposable Salivary Glucose Sensor for Diabetes Control.
Trial report in Journal of diabetes science and technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Saliva, a Magic Biofluid Available for Multilevel Assessment and a Mirror of General Health-A Systematic Review.Biosensors · 2019Pooled it
- Carbon Nanotube-Based Biosensors for Non-Invasive Biofluid Analysis.Biosensors · 2026Review
- Dipole moment as the underlying mechanism for enhancing the immobilization of glucose oxidase by ferrocene-chitosan for superior specificity non-invasive glucose sensing.Nanoscale advances · 2023Article
- Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices.Theranostics · 2022Review
- Continuous monitoring of diabetes with an integrated microneedle biosensing device through 3D printing.Microsystems & nanoengineering · 2021Article
- Survey of Saliva Components and Virus Sensors for Prevention of COVID-19 and Infectious Diseases.Biosensors · 2020Review
- Non-Invasive Electrochemical Biosensors Operating in Human Physiological Fluids.Sensors (Basel, Switzerland) · 2020Review
- Feasibility study of portable microwave microstrip open-loop resonator for non-invasive blood glucose level sensing: proof of concept.Medical & biological engineering & computing · 2019Article
- Glucose Concentration Measurement in Human Blood Plasma Solutions with Microwave Sensors.Sensors (Basel, Switzerland) · 2019Article
- Toward the Development of a Glucose Dehydrogenase-Based Saliva Glucose Sensor Without the Need for Sample Preparation.Journal of diabetes science and technology · 2018Article
- Sensing of Salivary Glucose Using Nano-Structured Biosensors.Biosensors · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelf-management of blood glucose (BG) is considered a norm for diabetes control. However, this invasive process is uncomfortable for patients, especially when intensive measurements with frequent finger pricks are required. Saliva, an alternative body fluid that is easily accessible and contains trace amount of glucose can be potentially used for the noninvasive monitoring of diabetes.
methodsAs a solution for real-time glucose measurements using saliva for diabetic care, we have developed an on-chip disposable glucose nano-biosensor through a layer-by-layer assembly process. In this work, a clinical study of 10 healthy subjects was conducted to determine the potential usefulness of salivary glucose (SG) sensors for glycemic control.
resultsFindings revealed (1) the individual BG/SG ratio at fasting was consistent over an entire year when there was no significant change of personal health; (2) the individual SG levels tracked closely with BG levels after meals; (3) a time difference of 15-30 minutes exists between peak levels of BG and SG; (4) 2 hours after a meal, the BG/SG ratio returned to a similar value at fasting.
conclusionsWe propose to measure fasting and pre- and 2-hour postprandial SG levels for self-management of glycemic levels. As a result, this article is not intended to replace the common BG tests. With preliminary results, we believe SG itself could be used as means for reliable diabetes monitoring and a potential fluid for prognosis of future disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.