ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2016
Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
284 citing papers in PubMed, 1 synthesis or guideline pooled it, 744 citations in OpenAlex.
- Systematic Review: Ultrasound Goes Echo-Decarbonising Inflammatory Bowel Disease Care Through Intestinal Ultrasound.Alimentary pharmacology & therapeutics · 2025Pooled it
- The role of empagliflozin-induced metabolic changes for cardiac function in patients with type 2 diabetes. A randomized cross-over magnetic resonance imaging study with insulin as comparator.Cardiovascular diabetology · 2024Trial
- The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis.European radiology · 2022Trial
- Randomized study of the effect of gadopiclenol, a new gadolinium-based contrast agent, on the QTc interval in healthy subjects.British journal of clinical pharmacology · 2020Trial
- Dosimetric Characterization Using Quantitative Magnetic Resonance Imaging of PAGAT and Gd-PAGAT Polymer Gel Dosimeters at High Gd Concentration.Gels (Basel, Switzerland) · 2026Article
- Rare Earth Elements in Testicular Function: Current Knowledge and Future Directions.International journal of molecular sciences · 2026Review
- Tuning Core Fluidity in Emulsion Nanoparticles for Stable and Transition-Metal-Free Responsive 19F MRI Probes.Journal of the American Chemical Society · 2026Article
- The Emerging Role of Ultrasonography in Ulcerative Colitis.Diagnostics (Basel, Switzerland) · 2026Review
- Magnetite nanodiscs as vortex-enhanced MRI contrast agents: a novel approach in medical imaging.Nanoscale advances · 2026Article
- Early Radiation Therapy Response Assessment Using Multi-Scale Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cerebral blood flow and time of exchange measurements using multi-TE blood-brain barrier arterial spin labeling MRI in IDH mutational subgroups of gliomas.Magma (New York, N.Y.) · 2026Article
- Gadolinium-based contrast agents in pediatric MRI: renal safety, risk mitigation, and emerging alternatives.Pediatric radiology · 2026Review
- Article
- Gadolinium Nanoparticles: Emerging Platforms Beyond Imaging for Drug Delivery and Theranostics.Pharmaceutics · 2026Review
- A Comprehensive Review on Filled Carbon Nanotubes: Synthesis, Properties and Applications.Chemical reviews · 2026Review
- Repeatability of diffusion-weighted arterial spin labeling MRI for mapping blood-brain barrier water exchange rate at different postlabel delays.Magnetic resonance in medicine · 2026Article
- Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Gadolinium-based contrast agent-free (GBCA-free) versus gadolinium-based contrast agent-enhanced (GBCA-enhanced) magnetic resonance imaging as a screening tool for intracranial tumors.Frontiers in neuroimaging · 2026Article
- Progress in the Development of Metal-Organic Frameworks (MOFs) for Medical Imaging of Tumors: Prospects and Challenges.International journal of nanomedicine · 2026Review
- Myocardial radiomics of non-ischemic cardiomyopathy using cardiovascular magnetic resonance: current perspectives and future directions.Frontiers in cardiovascular medicine · 2026Review
224 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gadolinium chelates are widely used as contrast media for magnetic resonance imaging. The approved gadolinium-based contrast agents (GBCAs) have historically been considered safe and well tolerated when used at recommended dosing levels. However, for nearly a decade, an association between GBCA administration and the development of nephrogenic systemic fibrosis (NSF) has been recognized in patients with severe renal impairment. This has led to modifications in clinical practices aimed at reducing the potential and incidence of NSF development. Newer reports have emerged regarding the accumulation of gadolinium in various tissues of patients who do not have renal impairment, including bone, brain, and kidneys. Despite the observations of gadolinium accumulation in tissues regardless of renal function, very limited clinical data regarding the potential for and mechanisms of toxicity is available. This significant gap in knowledge warrants retrospective cohort study efforts, as well as prospective studies that involve gadolinium ion (Gd(3+)) testing in patients exposed to GBCA. This review examines the potential biochemical and molecular basis of gadolinium toxicity, possible clinical significance of gadolinium tissue retention and accumulation, and methods that can limit gadolinium body burden.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.