ArticleScientific reports2016
Effects of Morphology Constraint on Electrophysiological Properties of Cortical Neurons.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Interrogating functional connectivity of in vitro neural glia tissue model modulated through integrative control of matrix stiffness and a neurotrophic factor.Biomaterials · 2026Article
- Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase.Brain structure & function · 2025Article
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.Cell reports · 2024Article
- A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites.PLoS computational biology · 2024Article
- Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli.bioRxiv : the preprint server for biology · 2023Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Morpho-Electric Properties and Diversity of Oxytocin Neurons in Paraventricular Nucleus of Hypothalamus in Female and Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Label-free monitoring of 3D cortical neuronal growthBiomedical optics express · 2021Article
- Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia.International journal of molecular sciences · 2021Article
- Interpreting the Entire Connectivity of Individual Neurons in Micropatterned Neural Culture With an Integrated Connectome Analyzer of a Neuronal Network (iCANN).Frontiers in neuroanatomy · 2021Article
- Article
- Illuminating dendritic function with computational models.Nature reviews. Neuroscience · 2020Review
- Hyperexcitability and plasticity induced by sustained hypoxia on rectus abdominis motoneurons.The Journal of physiology · 2019Article
- Dependence and Homeostasis of Membrane Impedance on Cell Morphology in Cultured Hippocampal Neurons.Scientific reports · 2018Article
- Single-cell analysis of diversity in human stem cell-derived neurons.Cell and tissue research · 2018Review
- Controlled placement of multiple CNS cell populations to create complex neuronal cultures.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing interest in engineering nerve cells in vitro to control architecture and connectivity of cultured neuronal networks or to build neuronal networks with predictable computational function. Pattern technologies, such as micro-contact printing, have been developed to design ordered neuronal networks. However, electrophysiological characteristics of the single patterned neuron haven't been reported. Here, micro-contact printing, using polyolefine polymer (POP) stamps with high resolution, was employed to grow cortical neurons in a designed structure. The results demonstrated that the morphology of patterned neurons was well constrained, and the number of dendrites was decreased to be about 2. Our electrophysiological results showed that alterations of dendritic morphology affected firing patterns of neurons and neural excitability. When stimulated by current, though both patterned and un-patterned neurons presented regular spiking, the dynamics and strength of the response were different. The un-patterned neurons exhibited a monotonically increasing firing frequency in response to injected current, while the patterned neurons first exhibited frequency increase and then a slow decrease. Our findings indicate that the decrease in dendritic complexity of cortical neurons will influence their electrophysiological characteristics and alter their information processing activity, which could be considered when designing neuronal circuitries.
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