Evidence map›Paper›PMID 27052632›Full record

ReviewHNO2016

Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck.

M Mandapathil

Abstract readReview
PubMed Publisher
In one paragraph

Review in HNO, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Targeted knockdown of the adenosine AMolecular therapy. Methods & clinical development · 2021
    Article
  2. PD1 blockade enhances KJournal for immunotherapy of cancer · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

M MandapathilKlinik für Hals-Nasen-Ohrenheilkunde, Kopf-Hals-Chirurgie, Philipps-Universität Marburg, Baldingerstrasse 1, 35043, Marburg, Deutschland. mandapat@med.uni-marburg.de.
Philipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review article describes the potential role of ectonucleotidase activity, adenosine metabolism, and the adenosinergic signaling pathway in the suppression of the host immune system in patients with head and neck cancer. Identifying such mechanisms leads to a better understanding of immunosuppressive mechanisms in this patient population. Further, potential targets for immunotherapy in an adjuvant approach to treating squamous cell carcinoma of the head and neck in the future might be identified and improve the prognosis of these patients.

Indexed as

AdenosineCarcinoma, Squamous CellCell SurvivalHead and Neck NeoplasmsHumansImmunity, InnateImmunomodulationImmunosuppressive AgentsModels, ImmunologicalSquamous Cell Carcinoma of Head and NeckAdenosineImmunosuppressive AgentsAdenosineHead and neck cancerImmunotherapyRegulatory T cellsSignaling pathways

Identifiers

PMID27052632
OpenAlexW2338349807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.