ArticleBMC microbiology2016
Haemophilus parainfluenzae as a marker of the upper respiratory tract microbiota changes under the influence of preoperative prophylaxis with or without postoperative treatment in patients with lung cancer.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Insights into Haemophilus macrolide resistance: A comprehensive systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Epidemiology and antimicrobial resistance trends inMicrobiology spectrum · 2026Article
- Fecal calprotectin and gut microbiome in a cohort without intestinal pathologies from northern Italy.iScience · 2026Article
- Bronchial and Systemic Relationships ofInternational journal of molecular sciences · 2026Article
- Dysbiosis associated with enhanced microbial mobility across the respiratory tract in pulmonary tuberculosis patients.BMC microbiology · 2025Article
- A novel capsular operon and potentially conjugative plasmids in extensively drug-resistant urogenitalFrontiers in microbiology · 2025Article
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- Designing of a multi-epitopes based vaccine againstFrontiers in immunology · 2024Article
- Development of DNA Microarray for Parallel Detection of Community-Acquired Pneumonia Bacterial Pathogens.Sovremennye tekhnologii v meditsine · 2024Article
- Dynamic microbial changes in exacerbation of chronic obstructive pulmonary disease.Frontiers in microbiology · 2024Article
- Subtype-Based Microbial Analysis in Non-small Cell Lung Cancer.Tuberculosis and respiratory diseases · 2023Article
- The respiratory tract microbiome, the pathogen load, and clinical interventions define severity of bacterial pneumonia.Cell reports. Medicine · 2023Article
- Characterization of the Lower Airways and Oral Microbiota in Healthy Young Persons in the Community.Biomedicines · 2023Article
- Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment.Microbiology spectrum · 2023Article
- Infective Endocarditis Due to Haemophilus parainfluenzae: A Case Report and Review of the Literature.Journal of Brown hospital medicine · 2023Article
- Microbial Biomarkers for Lung Cancer: Current Understandings and Limitations.Journal of clinical medicine · 2022Review
- Mechanisms underlying interactions between two abundant oral commensal bacteria.The ISME journal · 2022Article
- Lung microbiota features of stage III and IV non-small cell lung cancer patients without lung infection.Translational cancer research · 2022Article
- Intratumoral Microbiota Impacts the First-Line Treatment Efficacy and Survival in Non-Small Cell Lung Cancer Patients Free of Lung Infection.Journal of healthcare engineering · 2022Article
- The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID-19 Patients.BioMed research international · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHaemophili are representative microbiota of the upper respiratory tract. The aim of this study was to assess the effects of perioperative antimicrobial prophylaxis and/or postoperative treatment on Haemophilus parainfluenzae prevalence, and antimicrobial sensitivity in short-term hospitalized patients with lung cancer who underwent surgery.
resultsSamples were collected from 30 short-term hospitalized patients with lung cancer and from 65 healthy people. The nasal and throat specimens were taken twice from each patient: before (EI, Examination I), on the fourth/fifth day (EII, Examination II) after surgery, and once from healthy people. The isolates identification and antimicrobial susceptibility were detected by routine diagnostic methods. H. parainfluenzae was found in throat specimens of 42/65 (64.6 %) healthy people, while in 19/30 (63.3 %) lung cancer patients in EI (p = 0.6203) and in 13/30 (43.3 %) ones in EII (p = 0.0106). Neither the disease itself nor short-term hospitalization with perioperative prophylaxis alone affected H. parainfluenzae prevalence in EII, while perioperative prophylaxis with postoperative treatment significantly decreased its colonization in EII. The differences in the number of patients colonized by Candida spp. in EI and in EII were observed (p = 0.0082).Totally, 23/58 (39.7 %) of H. parainfluenzae isolates were resistant mainly to beta-lactams; among 11 ampicillin-resistant isolates only 3 were beta-lactamase positive.
conclusionsThe antimicrobial perioperative prophylaxis together with postoperative treatment may disturb the composition of the airways microbiota represented by H. parainfluenzae, in addition to selecting the resistant strains of bacteria and promoting yeasts colonization in lung cancer patients undergoing surgery.
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