ReviewJournal of neurophysiology2016
Strategies for targeting primate neural circuits with viral vectors.
Review in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Optotagging in primate cortex uncovers excitatory and inhibitory neuron specializations in form vision.Nature communications · 2026Article
- Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey.Scientific reports · 2026Article
- Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain.Cell reports methods · 2026Article
- Retrograde transduction of dopaminergic cells in substantia nigra of rhesus monkey.bioRxiv : the preprint server for biology · 2026Article
- Clarifying the neural circuit mechanisms of spontaneous social behavior in macaques.Frontiers in neural circuits · 2026Article
- Tracing of specific neural pathways in the rat brain using lentiviral vectors for retrograde gene transfer.Anatomical science international · 2025Article
- Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity.Neuroscience bulletin · 2024Review
- Genetic Approaches for Neural Circuits Dissection in Non-human Primates.Neuroscience bulletin · 2023Review
- Preferential transduction of parvalbumin-expressing cortical neurons by AAV-mDLX5/6 vectors.Frontiers in neuroscience · 2023Article
- Viral Tools for Neural Circuit Tracing.Neuroscience bulletin · 2022Review
- Nigral neuropathology of Parkinson's motor subtypes coincide with circuitopathies: a scoping review.Brain structure & function · 2022Article
- Wireless, battery-free, subdermally implantable platforms for transcranial and long-range optogenetics in freely moving animals.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cortical hierarchy, dual counterstream architecture and the importance of top-down generative networks.NeuroImage · 2021Review
- Control of Microbial Opsin Expression in Stem Cell Derived Cones for Improved Outcomes in Cell Therapy.Frontiers in cellular neuroscience · 2021Article
- Nonhuman Primate Optogenetics: Current Status and Future Prospects.Advances in experimental medicine and biology · 2021Review
- Using rAAV2-retro in rhesus macaques: Promise and caveats for circuit manipulation.Journal of neuroscience methods · 2020Review
- Histological assessment of optogenetic tools to study fronto-visual and fronto-parietal cortical networks in the rhesus macaque.Scientific reports · 2020Article
- Lentiviral vector-mediated transduction of adult neural stem/progenitor cells isolated from the temporal tissues of epileptic patients.Iranian journal of basic medical sciences · 2020Article
- Illusions, Delusions, and Your Backwards Bayesian Brain: A Biased Visual Perspective.Brain, behavior and evolution · 2020Review
- Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation.Frontiers in neuroanatomy · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding how the brain works requires understanding how different types of neurons contribute to circuit function and organism behavior. Progress on this front has been accelerated by optogenetics and chemogenetics, which provide an unprecedented level of control over distinct neuronal types in small animals. In primates, however, targeting specific types of neurons with these tools remains challenging. In this review, we discuss existing and emerging strategies for directing genetic manipulations to targeted neurons in the adult primate central nervous system. We review the literature on viral vectors for gene delivery to neurons, focusing on adeno-associated viral vectors and lentiviral vectors, their tropism for different cell types, and prospects for new variants with improved efficacy and selectivity. We discuss two projection targeting approaches for probing neural circuits: anterograde projection targeting and retrograde transport of viral vectors. We conclude with an analysis of cell type-specific promoters and other nucleotide sequences that can be used in viral vectors to target neuronal types at the transcriptional level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.