SynthesisGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology2016
Insulin resistance in obesity and polycystic ovary syndrome: systematic review and meta-analysis of observational studies.
Synthesis in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04151459 (Effect of Laparoscopic Sleeve Gastrectomy), which is not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Laparoscopic Sleeve Gastrectomy (LSG) on Live Birth Rate of Offspring in Polycystic Ovarian Syndrome (PCOS) Patients With Severely Obese
Open the trial in the graphWho cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The association between triglyceride-glucose index and polycystic ovary syndrome: a systematic review and meta-analysis across different populations.Journal of ovarian research · 2025Pooled it
- Health-related physical fitness in women with polycystic ovary syndrome versus controls: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Lifestyle changes in women with polycystic ovary syndrome.The Cochrane database of systematic reviews · 2019Pooled it
- Association between periodontal disease and polycystic ovary syndrome: a systematic review.International journal of impotence research · 2017Pooled it
- Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial.Journal of ovarian research · 2024Trial
- Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome.Chinese journal of integrative medicine · 2021Trial
- Effect of phlebotomy versus oral contraceptives containing cyproterone acetate on the clinical and biochemical parameters in women with polycystic ovary syndrome: a randomized controlled trial.Journal of ovarian research · 2019Trial
- Cognitive-behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: a pilot randomized clinical trial.Fertility and sterility · 2018Trial
- The Relationship Between Aortic Knob Width and Metabolic Syndrome in Women with Polycystic Ovary Syndrome.Journal of clinical medicine · 2026Article
- Obesity and female reproductive health in Asian population.Obesity pillars · 2026Review
- Molecular Mechanisms Underlying Reproductive Dysfunction in Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Androgenetic alopecia in polycystic ovary syndrome: a cutaneous marker of systemic metabo-inflammatory and endocrine dysfunction.Endocrine connections · 2026Review
- Prediction of cardiovascular disease risk in women and individuals with polycystic ovary syndrome using the American Heart Association PREVENT model: A long-term population-based cohort study.American journal of preventive cardiology · 2026Article
- ApoB and LDL partially explain the association between family history of diabetes and lower clinical pregnancy in women who conceived with PCOS.Frontiers in nutrition · 2026Article
- Assessing the Discriminative Power of Metabolic Indices for PMOS Detection in Normal-Weight Women.International journal of women's health · 2026Article
- Recent advances in reprogramming lactate metabolism in polycystic ovary syndrome.Journal of ovarian research · 2025Review
- Exploring 1400 Plasma Metabolites and Polycystic Ovary Syndrome: A Bidirectional Mendelian Randomization Study.Brain and behavior · 2025Article
- Longitudinal trajectories of insulin resistance in women with polycystic ovary syndrome: a functional data analysis approach.Endocrine connections · 2025Article
- Epidemiological features of uterine fibroid-associated imaging changes in Chinese women of reproductive age: a retrospective study.BMJ open · 2025Observational
- Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association.Human reproduction update · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed at investigating whether insulin resistance (IR)/sensitivity are impaired in obese/non-obese polycystic ovary syndrome (PCOS) and obese/non-obese healthy controls. A comprehensive literature search was performed for observational, English language studies. Meta-analysis was performed with the random effects model according to the heterogeneity. Eligible studies, involving 3037 women in four groups of: 1-obese, PCOS; 2-non-obese, PCOS, 3-obese, non-PCOS and 4-Non-obese, non-PCOS were included. Based on the insulin resistance index (HOMA-IR) analysis, the pooled mean (95% Conf. Interval) of HOMA IR in groups 1-4 were 4.38 (3.84, 4.92), 2.68 (2.16, 3.20), 2.44 (2.06, 2.82) and 1.34 (1.06, 1.63), respectively. Meta-analysis showed that group 1 (obese, PCOS patients) statistically have the highest IR and group 4 (non-obese, non-PCOS women) have the highest insulin sensitivity. Group 2 (non-obese, PCOS patients) and group 3 (obese, non-PCOS women) were between this range and they had lower IR than group 1 (obese, PCOS) and lower insulin sensitivity than group 4 (non-obese, non-PCOS). So, there were statistical differences between all groups except between groups 2 and 3. Insulin sensitivity indexes (quickie and ISI), also confirm the IR index (HOMA-IR) results. Based on different IR/sensitivity indexes, we found no evidence of any different effects of BMI ≥ 30 kg/m(2) on IR/sensitivity. In conclusion, PCOS status intensifies the adverse effects of obesity on IR, it has to be appropriately addressed in primary and secondary preventive cares and treatments provided for these women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.