Evidence map›Paper›PMID 27052371›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2016

Evaluation of fluorescence imaging with indocyanine green in hepatocellular carcinoma.

Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Hiroya Iida, Tatsuma Sakaguchi, Takumi Tsuda, Tadayoshi Okumura, Kentaro Inoue, Shingo Shimada, Seiji Ohtsubo and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Masaki KaiboriDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan. kaibori@hirakata.kmu.ac.jp.
Kosuke MatsuiDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Morihiko IshizakiDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Hiroya IidaDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Tatsuma SakaguchiDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Takumi TsudaDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Tadayoshi OkumuraDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Kentaro InoueDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Shingo ShimadaDepartment of Surgery, Japan Labour Health and Welfare Organization Kushiro Rosai Hospital, Kushiro, Japan.
Seiji OhtsuboDepartment of Oral and Maxillofacial Surgery, Japan Labor Health and Welfare Organization Kushiro Rosai Hospital, Kushiro, Japan.
Mitsuo KusanoDepartment of Surgery, Seiwa Memorial Hospital, Sapporo, Hokkaido, Japan.
Yuzuru IkeharaResearch Centre for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.
Eiichi OzekiTechnology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Tomoki KitawakiDepartment of Mathematics, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan.
Masanori KonDepartment of Surgery, Hirakata Hospital, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.
Kansai Medical University · JPKushiro Rosai Hospital · JPNational Institute of Advanced Industrial Science and Technology · JPSeiwa Hospital · JPShimadzu (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe hypothesized that indocyanine green (ICG) fluorescence patterns using Clairvivo OPT in resected liver specimens could confirm hepatocellular carcinoma (HCC) better than earlier commercial imaging systems. This preclinical trial evaluated the effectiveness of fluorescence imaging as an intraoperative cancer navigation tool.

methodsICG fluorescence images of resected specimens from 190 patients with HCC were classified into two groups according to whether high fluorescence was seen in the HCC (high cancerous [HC] group) or in the surrounding liver tissue (high surrounding [HS] group). The HC and HS groups were sub-classified into whole and partial types and whole and ring types, respectively.

resultsThe HC group had significantly higher prevalence of esophageal or gastric varices, and worse liver function than patients in the HS group. The HC group also had a higher percentage of limited resection cases than did the HS group. Cirrhotic liver histology was significantly more common in the HC group than in the HS group. Multivariate analysis revealed that the HC group was a predictive factor for cirrhosis in HCC patients. Among the HC patients, a higher percentage of well-differentiated HCC cases were seen in the partial-type subgroup than in the whole-type subgroup (23/48 (48 %) vs. 7/68 (10 %)). In the HS group, the ring-type subgroup had a higher percentage of poorly differentiated HCC cases than did the whole-type subgroup (6/37 (16 %) vs. 0/37 (0 %)).

conclusionTumor differentiation and fibrosis in the non-cancerous liver parenchyma could affect ICG fluorescence imaging in HCC. ICG fluorescence imaging may be a good indication for fibrosis stage. In future, we will try to evaluate fluorescence imaging with ICG for intraoperative cancer navigation in HCC, using a portable near-infrared fluorescence imaging system.

Indexed as

Coloring AgentsIndocyanine GreenAdministration, IntravenousAgedCarcinoma, HepatocellularEsophageal and Gastric VaricesFemaleHepatectomyHumansInfrared RaysIntraoperative CareLasers, SemiconductorLiverLiver CirrhosisLiver NeoplasmsMaleColoring AgentsIndocyanine GreenFibrosis stageHepatic resectionHepatocellular carcinomaIndocyanine green fluorescence imaging

Identifiers

PMID27052371
PMCPMC4823845
OpenAlexW2312406810

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.