Evidence map›Paper›PMID 27052111›Full record

ArticleNature communications2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Alexander Gusev, Huwenbo Shi, Gleb Kichaev, Mark Pomerantz, Fugen Li, Henry W Long, Sue A Ingles, Rick A Kittles, Sara S Strom, Benjamin A Rybicki and 119 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

129 authors.

Alexander GusevProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Huwenbo ShiBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.
Gleb KichaevBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.
Mark PomerantzDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.
Fugen LiCenter for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Henry W LongDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.
Sue A InglesDepartment of Preventative Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Rick A KittlesUniversity of Arizona College of Medicine and University of Arizona Cancer Center, Tucson, Arizona 85721, USA.
Sara S StromDepartment of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Barbara NemesureDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York 11794, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, Maryland 21205, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Curtis A PettawayDepartment of Urology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Edward D YeboahKorle Bu Teaching Hospital, Accra, Ghana.
Yao TetteyKorle Bu Teaching Hospital, Accra, Ghana.
Richard B BiritwumKorle Bu Teaching Hospital, Accra, Ghana.
Andrew A AdjeiKorle Bu Teaching Hospital, Accra, Ghana.
Evelyn TayKorle Bu Teaching Hospital, Accra, Ghana.
Ann TrueloveWestat, Rockville, Maryland 20850, USA.
Shelley NiwaWestat, Rockville, Maryland 20850, USA.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, California 94720, USA.
Esther M JohnCancer Prevention Institute of California, Fremont, California 94538, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, Illinois 60611, USA.
Lisa B SignorelloProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
John CarptenThe Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.
M Cristina LeskeDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York 11794, USA.
Suh-Yuh WuDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York 11794, USA.
Anslem J M HennisDepartment of Preventive Medicine, Stony Brook University, Stony Brook, New York 11794, USA.
Christine Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Ann W HsingCancer Prevention Institute of California, Fremont, California 94538, USA.
Lisa ChuCancer Prevention Institute of California, Fremont, California 94538, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Eric A KleinGlickman Urological &Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94118, USA.
Graham CaseyDepartment of Preventative Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Sam KaggwaDepartment of Surgery, Makerere University College of Health Sciences, Kampala 94118, Uganda.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Daniel O StramDepartment of Preventative Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Rosalind A EelesThe Institute of Cancer Research, Sutton SM2 5NG, UK.
Douglas EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.
Zsofia Kote-JaraiThe Institute of Cancer Research, Sutton SM2 5NG, UK.
Ali Amin Al OlamaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.
Sara BenllochCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.
Kenneth MuirInstitute of Population Health, University of Manchester, Manchester M13 9PL, UK.
Graham G GilesCancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria 3004, Australia.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia.
Liesel M FitzgeraldCancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria 3004, Australia.
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm 171 77, Sweden.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm 171 77, Sweden.
Markus AlyDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm 171 77, Sweden.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California 90007, USA.
Johanna SchleutkerDepartment of Medical Biochemistry and Genetics Institute of Biomedicine Kiinamyllynkatu 10, University of Turku, Turku FI-20014, Finland.
Tiina WahlforsBioMediTech, University of Tampere and FimLab Laboratories, Tampere 33200, Finland.
Teuvo L J TammelaDepartment of Urology, Tampere University Hospital and Medical School, University of Tampere, Tampere 33200, Finland.
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev DK-2730, Denmark.
Tim J KeyCancer Epidemiology, Nuffield Department of Population Health; University of Oxford, Oxford OX3 7LF, UK.
Ruth C TravisCancer Epidemiology, Nuffield Department of Population Health; University of Oxford, Oxford OX3 7LF, UK.
David E NealUniversity of Cambridge, Department of Oncology, Addenbrooke's Hospital, Box 279, Hills Road, Cambridge CB2 0QQ.
Jenny L DonovanSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
Freddie C HamdyDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus OX1 3PN, Denmark.
Paul PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.ORCID http://orcid.org/0000-0001-8494-732X
Nora PashayanCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge CB1 8RN, UK.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
Stephen N ThibodeauMayo Clinic, Rochester, Minnesota 55905, USA.
Shannon K McDonnellMayo Clinic, Rochester, Minnesota 55905, USA.
Daniel J SchaidMayo Clinic, Rochester, Minnesota 55905, USA.
Christiane MaierInstitute of Human Genetics, University Hospital Ulm, 89081 Ulm, Germany.
Walther VogelInstitute of Human Genetics, University Hospital Ulm, 89081 Ulm, Germany.
Manuel LuedekeDepartment of Urology, University Hospital Ulm, 89081 Ulm, Germany.
Kathleen HerkommerDepartment of Urology, Klinikum rechts der Isar der Technischen Universitaet Muenchen, 81675 Munich, Germany.
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, Dana-Farber Cancer Institute, 75 Francis Street, Boston, Massachusetts 02115, USA.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Dominika WokolorczykInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Wojciech KluzniakInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Lisa Cannon-AlbrightDivision of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
Craig TeerlinkDivision of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Aida K DieffenbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA.
Hui-Yi LinBiostatistics Program, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612, USA.
Chavdar SlavovDepartment of Urology and Alexandrovska University Hospital, Medical University, Sofia 1431, Bulgaria.
Radka KanevaDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University, Sofia, 2 Zdrave Str., Sofia 1431, Bulgaria.
Vanio MitevDepartment of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University, Sofia, 2 Zdrave Str., Sofia 1431, Bulgaria.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Queensland 4000, Australia.
Amanda SpurdleMolecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4000, Australia.
Judith A ClementsAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Queensland 4000, Australia.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto 4200, Portugal.
Hardev PandhaThe University of Surrey, Guildford, Surrey GU2 7XH, UK.
Agnieszka MichaelThe University of Surrey, Guildford, Surrey GU2 7XH, UK.
Paula PauloDepartment of Genetics, Portuguese Oncology Institute, Porto 4200, Portugal.
Sofia MaiaDepartment of Genetics, Portuguese Oncology Institute, Porto 4200, Portugal.
Andrzej KierzekThe University of Surrey, Guildford, Surrey GU2 7XH, UK.
PRACTICAL consortium
David V ContiDepartment of Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Demetrius AlbanesNutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland 20892, USA.
Christine BergDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Daniele CampaGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
E David CrawfordUrologic Oncology, University of Colorado at Denver Health Sciences Center, Denver, Colorado 80230, USA.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
J Michael GazianoProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Edward GiovannucciProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Robert HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Mattias JohanssonInternational Agency for Research on Cancer, Lyon 69008, France.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
Sara LindströmProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Carmen NavarroDepartment of Epidemiology, Regional Health Authority, Murcia 30009, Spain.
Kim OvervadDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Afshan SiddiqDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Dimitrios TrichopoulosProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Paolo VineisHuGeF Foundation, Torino 10126, Italy.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Gosia TrynkaDivisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-6955-9529
Soumya RaychaudhuriBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Frederick R SchumacherDepartment of Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Alkes L PriceProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Matthew L FreedmanBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Christopher A HaimanDepartment of Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Bogdan PasaniucBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
PLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH, MURRAY, MEGAN B · 2015 to 2021
$20.4M
Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 13065Cancer Research UK 14136Cancer Research UK 15007Cancer Research UK 16491Cancer Research UK 17528Cancer Research UK 19170Cancer Research UK C12292/A11174Cancer Research UK C1281/A12014Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C16913/A6135Cancer Research UK C490/A10124Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A3354Cancer Research UK C5047/A7357Cancer Research UK C5047/A8384Cancer Research UK C522/A8649Cancer Research UK C8197/A10123Cancer Research UK C8197/A10865Cancer Research UK G0500966/75466Medical Research Council 75466Medical Research Council G0401527Medical Research Council G0500966Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MR/N003284/1NCI NIH HHS 1U19 CA148065NCI NIH HHS 1U19 CA148112NCI NIH HHS 1U19 CA148537NCI NIH HHS 1 U19 CA148537-01NCI NIH HHS CA098758NCI NIH HHS CA128978NCI NIH HHS CA54281NCI NIH HHS CA63464NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA042014NCI NIH HHS P30CA042014NCI NIH HHS P30 CA060553NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA68485NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA056678NCI NIH HHS R01CA056678NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA072818NCI NIH HHS R01 CA082664NCI NIH HHS R01CA082664NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA092579NCI NIH HHS R01CA092579NCI NIH HHS R01 CA128813NCI NIH HHS R01CA128813NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA188392NCI NIH HHS R01 CA193910NCI NIH HHS R01CA72818NCI NIH HHS R35 CA197449NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA188392NCI NIH HHS U01 CA194393NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NIAID NIH HHS U19 AI111224NIAMS NIH HHS R01 AR063759NIEHS NIH HHS R01 ES011126NIGMS NIH HHS F32 GM106584NIGMS NIH HHS R01 GM105857NIGMS NIH HHS R01 GM107427NIMH NIH HHS R01 MH101244Wellcome Trust 076113Wellcome Trust 102215World Health Organization 001
6 · The paper itself

Abstract

Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.

Indexed as

Black or African AmericanEpigenesis, GeneticGenetic Predisposition to DiseaseInheritance PatternsWhite PeopleAcetylationAtlases as TopicCell Line, TumorGenetic LociGenome-Wide Association StudyHistonesHumansLinkage DisequilibriumMalePolymorphism, Single NucleotideProstatic NeoplasmsHistones

Identifiers

PMID27052111
PMCPMC4829663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.