Trial reportCirculation. Arrhythmia and electrophysiology2016
Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.
Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Circulation. Arrhythmia and electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Atrial Fibrillation Recurrence Reduction: What Treatments Work Best Postablation? A Network Meta-Analysis.Journal of cardiovascular electrophysiology · 2025Pooled it
- Effect of Exercise Training with Consideration of Potential Moderating Variables in Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis.Sports medicine - open · 2025Pooled it
- Prevalence and Risk Factors of Frailty in Stroke Patients: A Meta-Analysis and Systematic Review.The journal of nutrition, health & aging · 2023Pooled it
- Management of atrial fibrillation for older people with frailty: a systematic review and meta-analysis.Age and ageing · 2019Pooled it
- eHealth Tools to Provide Structured Assistance for Atrial Fibrillation Screening, Management, and Guideline-Recommended Therapy in Metropolitan General Practice: The AF - SMART Study.Journal of the American Heart Association · 2019Trial
- Effects of Rhythm Control versus Rate Control on Atrial Fibrillation and Frailty Development in Older Patients: Protocol for the Cardioversion of Atrial Fibrillation and Frailty in the Elderly (CAFFE) Study, an Observational, Prospective Cohort Study.JMIR research protocols · 2026Article
- Validity, reliability and clinical utility of the Glittre ADL test in patients with atrial fibrillation.Open heart · 2026Article
- Association between Physical Function and Incidence of Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study.medRxiv : the preprint server for health sciences · 2026Article
- Thyrotoxicosis in MCT8 deficiency.The Journal of clinical endocrinology and metabolism · 2026Review
- Telomere Shortening Drives Atrial Fibrillation Through VCAM-1 Mediated Atrial Electrical and Structural Remodeling.Aging cell · 2026Article
- Sarcopenia in atrial fibrillation: a prospective study.Turkish journal of medical sciences · 2026Article
- Management of Atrial Fibrillation in Elderly Patients: A Whole New Ballgame?Journal of clinical medicine · 2025Review
- Patient Characteristics and Real-World Treatment of Very Elderly Patients with Nonvalvular Atrial Fibrillation in Japan: An Administrative Claims Database Study.Cardiology and therapy · 2025Article
- Different effects of catheter ablation on exercise tolerance, leg strength, and quality of life in paroxysmal versus persistent atrial fibrillation.Journal of arrhythmia · 2025Article
- Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions.The journal of cardiovascular aging · 2025Article
- Atrial fibrillation accelerates functional decline in older adults: a 15-year follow-up population-based study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Anesthetic Choice for Percutaneous Transcatheter Closure of the Left Atrial Appendage: A National Anesthesia Clinical Outcomes Registry Analysis.Annals of cardiac anaesthesia · 2024Article
- Racial and Gender Differences in Cardiorespiratory Fitness and Atrial Fibrillation.Reviews in cardiovascular medicine · 2024Review
- Inflammation Burden and Atrial Fibrillation Burden: A Bidirectional Relationship.Arquivos brasileiros de cardiologia · 2024Article
- Association Between Chronic Diseases and Frailty in a Sample of Older Greek Inpatients.Cureus · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Jared W MagnaniFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.). jmagnani@bu.edu.
Na WangFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Emelia J BenjaminFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Melissa E GarciaFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Douglas C BauerFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Javed ButlerFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Patrick T EllinorFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Stephen KritchevskyFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Gregory M MarcusFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Anne NewmanFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Caroline L PhillipsFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Hiroyuki SasaiFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Suzanne SatterfieldFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Lisa M SullivanFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Tamara B HarrisFrom the Section of Cardiovascular Medicine, Boston University School of Medicine & National Heart, Lung and Blood Institute and Boston University's Framingham Heart Study, MA (J.W.M., E.J.B.); Department of Biostatistics, Boston University School of Public Health, MA (N.W., L.M.S.); Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD (M.E.G., C.L.P.); Division of General Internal Medicine, University of California, San Francisco (D.C.B.); Stony Brook University, NY (J.B.); Cardiovascular Research Center, Massachusetts General Hospital, Charlestown & Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston (P.T.E.); Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (P.T.E.); Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.K.); Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.); Department of Epidemiology, University of Pittsburgh, PA (A.N.); University of Tsukuba Faculty of Medicine, Tsukuba, Japan (H.S.); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (S.S.); and Geriatric Epidemiology Section, National Institute on Aging, Bethesda, MD (T.B.H.).
Health, Aging, and Body Composition Study
Funding
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MPeripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5MEnd of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7MAging and Inflammation: Longitudinal Markers and Genetics in the Framingham StudyR01AG028321 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2006 to 2010
$1.8MPatterns of Health Care Use, Treatment & Outcomes in Atrial Fibrillation: PATH-AFR01HL102214 · NHLBI · DUKE UNIVERSITY · PI BENJAMIN, EMELIA J., CURTIS, LESLEY H · 2010 to 2012
$1.4MMentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2MDYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996kRisk prediction of atrial fibrillation: clinical, biological and genetic markersRC1HL101056 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ALONSO, ALVARO, BENJAMIN, EMELIA J. · 2009 to 2010
$967kDYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793kAtrial fibrillation, functional decline, and arrhythmia detection in older adultsR03AG045075 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MAGNANI, JARED W. · 2013 to 2014
$151kHEALTH ABC--COORDINATING UNIT /California/-260062106N01AG062106 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1996 to 2004
$109kDoris Duke Charitable Foundation 2015084Intramural NIH HHSNHLBI NIH HHS 1K24HL105780NHLBI NIH HHS 1R01HL092577NHLBI NIH HHS 1R01HL102214NHLBI NIH HHS 1RC1HL101056NHLBI NIH HHS K24 HL105780NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL102214NHLBI NIH HHS RC1 HL101056NIA NIH HHS 1R01AG028321NIA NIH HHS N01-AG-62101NIA NIH HHS N01-AG-62103NIA NIH HHS N01-AG-62106NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG028050NIA NIH HHS R01AG028050NIA NIH HHS R01 AG028321NIA NIH HHS R03 AG045075NIA NIH HHS R03AG045075NINR NIH HHS R01 NR012459NINR NIH HHS R01-NR012459
Abstract
backgroundAge is the foremost risk factor for atrial fibrillation (AF), and AF has a rising prevalence in older adults. How AF may contribute to decline in physical performance in older adults has had limited investigation. We examined the associations of incident AF and 4-year interval declines in physical performance at ages 70, 74, 78, and 82 years in the Health, Aging, and Body Composition (Health ABC) Study. METHODS AND
resultsHealth ABC is a prospective cohort of community-dwelling older adults (n=3075). The study conducted serial assessments of physical performance with the Health ABC physical performance battery (scored 0-4), grip strength, 2-minute walk distance, and 400-m walking time. Incident AF was identified from the Center for Medicare and Medicaid Services and related to 4-year interval decline in physical performance. After exclusions, the analysis included 2753 Health ABC participants (52% women, 41% black race). Participants with AF had a significantly greater 4-year physical performance battery decline than those without AF at age 70, 74, 78, and 82, with mean estimated decline ranging from -0.08 to -0.10 U (95% confidence interval, -0.18 to -0.01; P<0.05 for all estimates) after multivariable adjustment. Grip strength, walk distance, and walk time similarly showed significantly greater declines at each 4-year age interval in participants with AF.
conclusionsIn community-based cohort older adults, incident AF was associated with increased risk of decline in physical performance. Further research is essential to identify mechanisms and preventive strategies for how AF may contribute toward declining physical performance in older adults.
Indexed as
AgingBody CompositionDisability EvaluationHealth StatusAgedAged, 80 and overAge FactorsAtrial FibrillationElectrocardiographyFemaleFollow-Up StudiesHumansMaleMotor ActivityPrevalenceProspective Studiesagingatrial fibrillationepidemiologymedicarephysical exercise
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