ArticleScience advances2016
Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- Genetic ancestry of families of putative Inka descent.Molecular genetics and genomics : MGG · 2018Trial
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- Demographic History of Indigenous Populations in Mexico Explored Through Whole Mitogenome Analysis.Genome biology and evolution · 2026Article
- Ancient DNA and spatial modeling reveal a pre-Inca trans-Andean parrot trade.Nature communications · 2026Article
- Continuity and discontinuity in Native American populations: Insights from ancient and modern mitochondrial DNA.Genetics and molecular biology · 2026Article
- Genetic insights into the peoples who shaped the American continent.Genetics and molecular biology · 2026Article
- Characterizing the American Upper Paleolithic.Science advances · 2025Review
- Human population history on the North Coast of peru from Y chromosomes and mitogenomes.Scientific reports · 2025Article
- Tracing Human Diversity in South America's Southern Cone: Linguistic, Morphometric, and Genetic Perspectives.American journal of biological anthropology · 2025Article
- Ancient dog mitogenomes support the dual dispersal of dogs and agriculture into South America.Proceedings. Biological sciences · 2025Article
- Moroccan genome project: genomic insight into a North African population.Communications biology · 2025Article
- Why humans evolved blue eyes.Frontiers in psychology · 2025Article
- Environmental conditions associated with initial northern expansion of anatomically modern humans.Nature communications · 2024Article
- High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia.Genes · 2023Article
- Genetic insights into Brazil's ancient shell mound builders.Nature ecology & evolution · 2023Article
- Insights into the genetic histories and lifeways of Machu Picchu's occupants.Science advances · 2023Article
- A paleogenome from a Holocene individual supports genetic continuity in Southeast Alaska.iScience · 2023Article
- Demographic history and genetic structure in pre-Hispanic Central Mexico.Science (New York, N.Y.) · 2023Article
37 more citing papers are in PubMed but not listed here.
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31 authors.
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Abstract
The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from eastern Beringia began to retreat. Genetic estimates of the timing and route of entry have been constrained by the lack of suitable calibration points and low genetic diversity of Native Americans. We sequenced 92 whole mitochondrial genomes from pre-Columbian South American skeletons dating from 8.6 to 0.5 ka, allowing a detailed, temporally calibrated reconstruction of the peopling of the Americas in a Bayesian coalescent analysis. The data suggest that a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages.
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