ArticleScience advances2016
Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed.
- Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance.Science advances · 2026Article
- Hyperpolarization of PyridineAngewandte Chemie (International ed. in English) · 2026Article
- HyperpolarizedACS sensors · 2026Article
- Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR-Spectroscopy.Angewandte Chemie (International ed. in English) · 2026Review
- Article
- Semi-Targeted Nuclear Magnetic Resonance Metabolomics via Parahydrogen-Induced Hyperpolarization for Enhanced Sensitivity to Metabolic Composition.Journal of the American Chemical Society · 2025Article
- The Versatility of Diazirines: Properties, Synthetic and Modern Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange.ChemMedChem · 2025Article
- Multi-axis fields boost SABRE hyperpolarization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-Journal of magnetic resonance open · 2023Article
- Delivering Robust Proton-Only Sensing of Hyperpolarized [1,2-ACS sensors · 2023Article
- Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.JACS Au · 2023Article
- Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions.Science advances · 2023Article
- Development of Dissolution Dynamic Nuclear Polarization of [Angewandte Chemie (International ed. in English) · 2023Article
- Reversible Parahydrogen Induced Hyperpolarization ofAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Spin dynamics of [1,2-Physical chemistry chemical physics : PCCP · 2023Article
- Parahydrogen in Reversible Exchange Induces Long-LivedAnalytical chemistry · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange.Molecules (Basel, Switzerland) · 2023Article
- NMR Discrimination of d- and l-α-Amino Acids at Submicromolar Concentration via Parahydrogen-Induced Hyperpolarization.Journal of the American Chemical Society · 2023Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
Conventional magnetic resonance (MR) faces serious sensitivity limitations which can be overcome by hyperpolarization methods, but the most common method (dynamic nuclear polarization) is complex and expensive, and applications are limited by short spin lifetimes (typically seconds) of biologically relevant molecules. We use a recently developed method, SABRE-SHEATH, to directly hyperpolarize (15)N2 magnetization and long-lived (15)N2 singlet spin order, with signal decay time constants of 5.8 and 23 minutes, respectively. We find >10,000-fold enhancements generating detectable nuclear MR signals that last for over an hour. (15)N2-diazirines represent a class of particularly promising and versatile molecular tags, and can be incorporated into a wide range of biomolecules without significantly altering molecular function.
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