Evidence map›Paper›PMID 27051592›Full record

ArticleBBA clinical2016

Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin.

Brian K McFarlin, Adam S Venable, Andrea L Henning, Jill N Best Sampson, Kathryn Pennel, Jakob L Vingren, David W Hill

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 6 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 6 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Antioxidants for preventing and reducing muscle soreness after exercise.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Review
  19. Review
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Brian K McFarlinApplied Physiology Laboratory, University of North Texas, Denton, TX, United States; Department of Biological Sciences, University of North Texas, Denton, TX, United States.
Adam S VenableApplied Physiology Laboratory, University of North Texas, Denton, TX, United States; Department of Biological Sciences, University of North Texas, Denton, TX, United States.
Andrea L HenningApplied Physiology Laboratory, University of North Texas, Denton, TX, United States; Department of Biological Sciences, University of North Texas, Denton, TX, United States.
Jill N Best SampsonApplied Physiology Laboratory, University of North Texas, Denton, TX, United States; Department of Biological Sciences, University of North Texas, Denton, TX, United States.
Kathryn PennelApplied Physiology Laboratory, University of North Texas, Denton, TX, United States.
Jakob L VingrenApplied Physiology Laboratory, University of North Texas, Denton, TX, United States; Department of Biological Sciences, University of North Texas, Denton, TX, United States.
David W HillApplied Physiology Laboratory, University of North Texas, Denton, TX, United States.
University of North Texas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise-Induced Muscle Damage (EIMD) and delayed onset muscle soreness (DOMS) impact subsequent training sessions and activities of daily living (ADL) even in active individuals. In sedentary or diseased individuals, EIMD and DOMS may be even more pronounced and present even in the absence of structured exercise.

methodsThe purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400 mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise). Subjects (N = 28) were randomly assigned to either curcumin (400 mg/day) or placebo (rice flour) and supplemented 2 days before to 4 days after EMID. Blood samples were collected prior to (PRE), and 1, 2, 3, and 4 days after EIMD to measure CK and inflammatory cytokines. Data were analyzed by ANOVA with P < 0.05.

resultsCurcumin supplementation resulted in significantly smaller increases in CK (- 48%), TNF-α (- 25%), and IL-8 (- 21%) following EIMD compared to placebo. We observed no significant differences in IL-6, IL-10, or quadriceps muscle soreness between conditions for this sample size.

conclusionsCollectively, the findings demonstrated that consumption of curcumin reduced biological inflammation, but not quadriceps muscle soreness, during recovery after EIMD. The observed improvements in biological inflammation may translate to faster recovery and improved functional capacity during subsequent exercise sessions. GENERAL SIGNIFICANCE: These findings support the use of oral curcumin supplementation to reduce the symptoms of EIMD. The next logical step is to evaluate further the efficacy of an inflammatory clinical disease model.

Indexed as

CytokinesInflammationLeg pressMultiplex

Identifiers

PMID27051592
PMCPMC4802396
OpenAlexW2284166181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.