Evidence map›Paper›PMID 27051520›Full record

ArticleJournal of therapeutic ultrasound2016

Assessing heating distribution by therapeutic ultrasound on bone phantoms and in vitro human samples using infrared thermography.

Gabriella Sellani, Dalila Fernandes, Abigail Nahari, Melissa Fabrício de Oliveira, Christiana Valois, Wagner C A Pereira, Christiano B Machado

Open access · hybridAbstract read
In one paragraph

Article in Journal of therapeutic ultrasound, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Gabriella SellaniBiomedical Ultrasound Laboratory (Applied Research Department), Estácio de Sá University, Rua do Bispo, n. 83 - Block F, Rio Comprido, Rio de Janeiro 20261-063 Brazil.
Dalila FernandesBiomedical Ultrasound Laboratory (Applied Research Department), Estácio de Sá University, Rua do Bispo, n. 83 - Block F, Rio Comprido, Rio de Janeiro 20261-063 Brazil.
Abigail NahariBiomedical Ultrasound Laboratory (Applied Research Department), Estácio de Sá University, Rua do Bispo, n. 83 - Block F, Rio Comprido, Rio de Janeiro 20261-063 Brazil.
Melissa Fabrício de OliveiraBiomedical Ultrasound Laboratory (Applied Research Department), Estácio de Sá University, Rua do Bispo, n. 83 - Block F, Rio Comprido, Rio de Janeiro 20261-063 Brazil.
Christiana ValoisGlobus Sports and Health Technology, Via Vittorio Veneto, 52, 31013 Codognè, TV Itália.
Wagner C A PereiraBiomedical Engineering Program, COPPE/Federal University of Rio de Janeiro, Av. Horácio Macedo, 2030. Technology Center, Block H - Room H327, Cidade Universitária, Rio de Janeiro, 21941-914 Brazil.
Christiano B MachadoBiomedical Ultrasound Laboratory (Applied Research Department), Estácio de Sá University, Rua do Bispo, n. 83 - Block F, Rio Comprido, Rio de Janeiro 20261-063 Brazil.
Estácio (Brazil) · BROspedale Civile di Vittorio Veneto · ITUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBioheat models have been proposed to predict heat distribution in multilayered biological tissues after therapeutic ultrasound (TUS) stimulation. However, evidence on its therapeutic benefit is still controversial for many clinical conditions. The aim of this study was to evaluate and to compare the TUS heating distribution on commercially available bone phantoms and in vitro femur and tibia human samples, at 1 MHz and several ultrasonic pulse regimens, by means of a thermographic image processing technique.

methodsAn infrared camera was used to capture an image after each 5-min 1-MHz TUS stimulation on bone phantoms, as well as in vitro femur and tibia samples (N = 10). An intensity-based processing algorithm was applied to estimate temperature distribution. Sections of five femurs in the coronal plane were also used for the evaluation of heat distribution inside the medullar canal.

resultsTemperature increased up to 8.2 and 9.8 °C for the femur and tibia, respectively. Moreover, the temperature increased up to 10.8 °C inside the medullar canal. Although temperature distributions inside the region of interest (ROI) were significantly different (p < 0.001), the average and standard deviation values for bone phantoms were more similar to the femur than to the tibia samples. Pulsed regimens caused lower increments in temperature than continuous sonication, as expected.

conclusionsCommercially available bone phantoms could be used in research focusing on thermal effects of ultrasound. Small differences in mean and standard deviation temperatures were observed between bone samples and phantoms. Temperature can reach more than 10 °C inside the medullar canal on a fixed probe position which may lead to severe cellular damage.

Indexed as

BioeffectsBoneHeatingIn vitro methodsTherapeutic ultrasoundTissue-mimicking phantoms

Identifiers

PMID27051520
PMCPMC4820859
OpenAlexW2346505719

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.