ReviewInterface focus2016
Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance.
Review in Interface focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Pharmacists' contribution to benzodiazepine deprescribing in older outpatients: a systematic review and meta-analysis.International journal of clinical pharmacy · 2023Pooled it
- Body weight variability and mortality in older adults: a nationwide population-based cohort study.Scientific reports · 2026Article
- Towards Caring Technologies in Older Adult Care Through the Co-Creation of an Ethical Process Guide.International journal of environmental research and public health · 2026Article
- Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes.Gels (Basel, Switzerland) · 2025Review
- Race course characteristics are the most important predictors in 48 h ultramarathon running.Scientific reports · 2025Article
- Does physical exercise enhance physical appearance? An empirical study based on CFPS.BMC public health · 2024Article
- Autonomic brain functioning and age-related health concerns.Current research in physiology · 2024Review
- An Optimal Dietary Pattern for Healthy Longevity: Scoping Differencing Review between the Mediterranean and the Japanese Diet.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Comparison of the management of Helicobacter pylori infection between the older and younger European populations.Scientific reports · 2023Article
- Integrating glycolysis, citric acid cycle, pentose phosphate pathway, and fatty acid beta-oxidation into a single computational model.Scientific reports · 2023Article
- Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model.PLoS computational biology · 2023Article
- An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity.Biogerontology · 2023Article
- Chronic exposure to dim light at night disrupts cell-mediated immune response and decreases longevity in aged female mice.Chronobiology international · 2022Article
- Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens.The Journal of biological chemistry · 2022Review
- Age-related macular degeneration and myeloproliferative neoplasms - A common pathway.Acta ophthalmologica · 2022Article
- Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review.Food science and biotechnology · 2022Review
- Review
- Dexamethasone-Loaded Bioactive Coatings on Medical Grade Stainless Steel Promote Osteointegration.Pharmaceutics · 2021Article
- COVID-19: A Challenge to Physiology of Aging.Frontiers in physiology · 2020Article
- Impaired cognition in geriatric patients with relation to earlier life mood disorder and traumatic brain injury: a hypothesis.Neuropsychiatric disease and treatment · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Ageing and lifespan are strongly affected by metabolism. The maximal possible uptake of oxygen is not only a good predictor of performance in endurance sports, but also of life expectancy. Figuratively speaking, healthy ageing is a competitive sport. Although the root cause of ageing is damage to macromolecules, it is the balance with repair processes that is decisive. Reduced or intermittent nutrition, hormones and intracellular signalling pathways that regulate metabolism have strong effects on ageing. Homeostatic regulatory processes tend to keep the environment of the cells within relatively narrow bounds. On the other hand, the body is constantly adapting to physical activity and food consumption. Spontaneous fluctuations in heart rate and other processes indicate youth and health. A (homeo)dynamic aspect of homeostasis deteriorates with age. We are now in a position to develop computational models of human metabolism and the dynamics of heart rhythm and oxygen transport that will advance our understanding of ageing. Computational modelling of the connections between dietary restriction, metabolism and protein turnover may increase insight into homeostasis of the proteins in our body. In this way, the computational reconstruction of human physiological processes, the Physiome, can help prevent frailty and age-related disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.