ArticleVeterinary world2016
Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats.
Article in Veterinary world, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Influence of Synbiotics on Selected Oxidative Stress Parameters.Oxidative medicine and cellular longevity · 2017Trial
- The Link Between Dysbiosis, Inflammation, Oxidative Stress, and Asthma-The Role of Probiotics, Prebiotics, and Antioxidants.Nutrients · 2024Review
- Protective effects of GuanXinNing tablet (GXNT) on diabetic encephalopathy in zucker diabetic obesity (ZDF) rats.BMC complementary medicine and therapies · 2023Article
- The self-nanoemulsifying drug delivery system ofVeterinary world · 2021Article
- Protective effects of Artemisia judaica extract compared to metformin against hepatorenal injury in high-fat diet/streptozotocine-induced diabetic rats.Environmental science and pollution research international · 2020Article
- Article
- The Effects of Synbiotic Supplementation on Glycemic Status, Lipid Profile, and Biomarkers of Oxidative Stress in Type 1 Diabetic Patients. A Placebo-Controlled, Double-Blind, Randomized Clinical Trial.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Targeting Altered Mitochondrial Biogenesis in the Brain of Diabetic Rats: Potential Effect of Pioglitazone and Exendin-4.Reports of biochemistry & molecular biology · 2019Article
- Impact of Metformin and Pioglitazone on Serum Level of Tumor Necrosis Factor-Alpha and Lipid Profiles during Implantation Window in Diabetic Rats.International journal of fertility & sterility · 2019Article
- Immunomodulatory Effects of Probiotics on Cytokine Profiles.BioMed research international · 2018Review
- Aqueous and alcoholic extracts ofAvicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe objective of the study was to assess the effect of combination treatment of insulin, pioglitazone and synbiotic on streptozotocin (STZ)-induced diabetic rats. MATERIALS AND
methodsDiabetes mellitus was induced chemically by intraperitoneal administration of STZ (40 mg/kg b.wt) to male Sprague-Dawley rats. The rats were divided randomly into six groups of six rats in each. Group 1 was maintained as a normal control. Group 2 was maintained as diabetic control; Group 3 was treated with insulin; Group 4 with insulin + synbiotic; Group 5 with insulin + pioglitazone; and Group 6 with insulin + synbiotic + pioglitazone. All the animals were treated for 60 days.
resultsBody weights, and concentration of reduced glutathione (GSH), and high-density lipoproteins cholesterol were significantly (p<0.05) reduced, whereas the concentration of blood glucose, total cholesterol, triglycerides, protein carbonyls and thiobarbituric acid reacting substances, and the activity of GSH peroxidase were significantly (p<0.05) elevated in Group 2 at the end of 8(th) week as compared to Group 1. The treatment Groups 3, 4, 5 and 6 revealed improvement in all the parameters, and the highest improvement was observed in combination Group 6.
conclusionFrom this study, it is concluded that combination of insulin, pioglitazone and synbiotic is useful in treating diabetes.
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