SynthesisDisease markers2016
Prognostic Value of Perineural Invasion in Esophageal and Esophagogastric Junction Carcinoma: A Meta-Analysis.
Synthesis in Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Development and internal validation of a prognostic model for esophageal cancer liver metastases using the Surveillance, Epidemiology, and End Results database.Journal of thoracic disease · 2026Article
- CT radiomics of adenocarcinoma of the esophagogastric junction: machine learning-based prediction of perineural invasion status.World journal of surgical oncology · 2026Article
- Association Between CDK4/CDK6 Expression and Prognosis in Patients with Adenocarcinoma of Gastroesophageal Junction.Digestive diseases and sciences · 2025Article
- Impact of perineural invasion in thoracic esophageal squamous cell carcinoma-a retrospective study with long-term follow-up outcomes.Journal of thoracic disease · 2025Article
- Radiomics to predict PNI in ESCC.Abdominal radiology (New York) · 2025Article
- The impact of perineural invasion on prognosis in esophageal cancer patients after surgery: a systematic review and meta-analysis.Frontiers in oncology · 2025Review
- Neoadjuvant chemotherapy versus surgery alone in locally advanced esophageal squamous cell carcinoma: a propensity-matched real-world study.Frontiers in oncology · 2025Article
- Use machine learning to predict pulmonary metastasis of esophageal cancer: a population-based study.Journal of cancer research and clinical oncology · 2024Article
- Article
- [Efficacy of machine learning modelsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Histological prognosticators in neoadjuvant naive oesophageal cancer patients.Langenbeck's archives of surgery · 2023Article
- Patterns and prognostic predictive value of perineural invasion in esophageal squamous cell carcinoma.BMC cancer · 2022Article
- Article
- What are the independent prognostic factors in patients undergoing esophagectomy for esophageal cancer?Turk gogus kalp damar cerrahisi dergisi · 2022Article
- Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer.The Journal of clinical investigation · 2021Review
- Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma.Thoracic cancer · 2021Article
- Impact of the extent of negative lymph nodes in gastric adenocarcinoma undergoing primary surgical resection: An institutional report.Journal of the Chinese Medical Association : JCMA · 2021Article
- Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma-An Emerging Role for Chemokines.Cancers · 2020Article
- Schwann cells shape the neuro-immune environs and control cancer progression.Cancer immunology, immunotherapy : CII · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHere we aimed to clarify the prognostic significance of perineural invasion (PNI) in esophageal and esophagogastric junction (EGJ) carcinoma.
methodsA comprehensive literature search for relevant reports published up to July 2015 was performed using Pubmed and Embase databases. The pooled HR and 95% CI for overall survival (OS) and disease-free survival (DFS) were used to assess the prognostic value. The association of PNI with pathological characteristics was evaluated by OR and 95% CI.
resultsA total of 13 cohorts were retrieved, covering 2770 patients treated by surgery. The cumulative analysis revealed a statistical correlation between PNI and poor OS (HR = 1.76, 95% CI: 1.54-2.20, and P < 0.00001), as well as poor DFS (HR = 1.96, 95% CI: 1.42-2.71, and P < 0.001). Moreover, analysis of 1475 patients showed improved PNI in T3 + T4 (OR = 0.39, 95% CI: 0.21-0.70, and P = 0.002), N+ (OR = 0.52, 95% CI: 0.40-0.69, and P < 0.00001), and G3 + G4 (OR = 0.66, 95% CI: 0.48-0.90, and P = 0.008) patients compared with T1 + T2, N-, and G1 + G2 ones, respectively. No significant heterogeneity was found between the studies.
conclusionsPNI is an adverse prognostic biomarker in esophageal and EGJ carcinoma. Moreover, PNI implies advanced T, N stage and poor cell differentiation.
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