ArticleProceedings of the National Academy of Sciences of the United States of America2016
Tracking brain arousal fluctuations with fMRI.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.
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Who cites it
199 citing papers in PubMed.
- Transcutaneous Auricular Vagus Nerve Stimulation Facilitates Cortical Arousal and Alertness.International journal of environmental research and public health · 2023Trial
- Modulation of simultaneously collected hemodynamic and electrophysiological functional connectivity by ketamine and midazolam.Human brain mapping · 2020Trial
- Global fluctuations of cerebral blood flow indicate a global brain network independent of systemic factors.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Trial
- Human single-neuron recordings reveal population coding of attentional dynamics during naturalistic movie viewing.bioRxiv : the preprint server for biology · 2026Article
- The dynamic functional connectivity peak index: Detection of interictal epileptic activity with fMRI.Epilepsia · 2026Article
- When Can Brain Connectivity Track the Working Mind? A Large-Scale Benchmark of Dynamic Functional Connectivity Across Cognitive Paradigms.bioRxiv : the preprint server for biology · 2026Article
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- Forecasting Perception Before It Happens: Context-Specific Connectivity Patterns Predict Perceptual Outcomes.bioRxiv : the preprint server for biology · 2026Article
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- System identification and surrogate data analyses imply approximate Gaussianity and non-stationarity of resting-brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Sleep alters neurovascular and hydrodynamic coupling in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Thalamic dynamics orchestrate the recovery of tonic alertness during nocturnal sleep inertia.Communications biology · 2026Article
- Arousal state alters brain network switching and moderates cognitive task performance.bioRxiv : the preprint server for biology · 2026Article
- Global cortical arousal effects in fMRI reveal brain markers of state and trait anxiety.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain.PLoS computational biology · 2026Article
- A low-variance subspace underlies individual differences in resting state fMRI.bioRxiv : the preprint server for biology · 2026Article
- Map-like representations of emotion knowledge in hippocampal-prefrontal systems.Nature communications · 2026Article
- Article
139 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Changes in brain activity accompanying shifts in vigilance and arousal can interfere with the study of other intrinsic and task-evoked characteristics of brain function. However, the difficulty of tracking and modeling the arousal state during functional MRI (fMRI) typically precludes the assessment of arousal-dependent influences on fMRI signals. Here we combine fMRI, electrophysiology, and the monitoring of eyelid behavior to demonstrate an approach for tracking continuous variations in arousal level from fMRI data. We first characterize the spatial distribution of fMRI signal fluctuations that track a measure of behavioral arousal; taking this pattern as a template, and using the local field potential as a simultaneous and independent measure of cortical activity, we observe that the time-varying expression level of this template in fMRI data provides a close approximation of electrophysiological arousal. We discuss the potential benefit of these findings for increasing the sensitivity of fMRI as a cognitive and clinical biomarker.
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