ArticlePloS one2016
Paucity of HPV-Related Head and Neck Cancers (HNC) in Nigeria.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human Papillomavirus-Associated Head and Neck Malignancies in Sub-Saharan Africa: A Systematic Review.JCO global oncology · 2023Pooled it
- Knowledge and attitudes of dental clinic attendees on oral HPV infection in Ibadan, Nigeria.BMC oral health · 2026Article
- Epidemiological Trends in the Characterization of Human Papillomavirus Virus-Related Oropharyngeal Cancer: A Global Perspective.Current oncology reports · 2025Review
- Review
- Incidence Characteristics and Histological Types of Head and Neck Cancer among Adults in Central Sudan: A Retrospective Study.International journal of environmental research and public health · 2022Article
- HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.Nature reviews. Clinical oncology · 2022Review
- Heterogeneity in head and neck cancer incidence among black populations from Africa, the Caribbean and the USA: Analysis of cancer registry data by the AC3.Cancer epidemiology · 2021Article
- Epidemiology of HPV Related Malignancies.Seminars in radiation oncology · 2021Review
- Characterization of high risk human papilloma virus genotypes associated with oropharyngeal cancers in a Nigerian population.The Pan African medical journal · 2021Article
- Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Cancers · 2020Review
- The interplay of HIV and human papillomavirus-related cancers in sub-Saharan Africa: scoping review.Systematic reviews · 2020Article
- Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review.BMC cancer · 2019Article
- Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study.Infectious agents and cancer · 2019Article
- Human papillomavirus in head and neck squamous cell carcinomas in a South African cohort.Papillomavirus research (Amsterdam, Netherlands) · 2018Article
- Identifying Risk Factors for Morbidity and Mortality in Patients with Primary Head and Neck Cancers in a Nigerian Population.Clinical Medicine Insights. Oncology · 2018Article
- Low prevalence of human papillomavirus in head and neck squamous cell carcinoma in the northwest region of the Philippines.PloS one · 2017Article
- Cancers Attributable to Alcohol Consumption in Nigeria: 2012-2014.Frontiers in oncology · 2017Article
- The burden of HPV associated cancers in two regions in Nigeria 2012-2014.Cancer epidemiology · 2016Article
- Burden of Cancers Attributable to Infectious Agents in Nigeria: 2012-2014.Frontiers in oncology · 2016Article
- Serum levels of single-carbon metabolism vitamins and homocysteine in head-and-neck squamous cell carcinoma: Preliminary report.Annals of African medicineArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
introductionThe burden of HPV-related Head and Neck Cancers (HNC) has been rising in the U.S. and other developed countries but this trend has not been reported in Africa. Objective of study was to evaluate the prevalence of HPV infection in HNC cancer cases seen between 1990 and 2011 at the tertiary health care institutions in Nigeria.
methodsWe retrieved 149 head and neck cancer formalin fixed, paraffin embedded tumor specimens diagnosed between 1990 and 2011 from four teaching hospitals in Nigeria. One hundred and twenty-three blocks (83%) contained appropriate HNC for analysis while DNA extraction was successful in 60% (90/149). PCR amplification was successful in 33% (49/149) and Linear Array genotyping for HPV was successful in 11% (17/149) of these cases. These were in tumors from the larynx (6), cervical lymph nodes (3), nasal cavity (2), parotid (1), palate (1), maxillary sinus (1) and mandible (1). Two cases were non-specific and none were from the oropharynx. Histologically, 41% (7/17) of the successfully genotyped blocks were squamous cell carcinomas (larynx 6, maxillary sinus 1). RESULTS AND
conclusionWe were unable to detect HPV in any of the HNC samples in our study. Our result may suggest that there is a low prevalence of HPV-related HNC among the adult population in Nigeria. Our results provide a benchmark to compare future incidence of HPV -related HNC in this community in future. We had significant analytical challenges from possible poor tissue processing and urge that future studies should prospectively collect samples and ensure high quality sample processing.
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