ReviewJournal of plastic surgery and hand surgery2016
Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances.
Review in Journal of plastic surgery and hand surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Collagenase Versus Operative Management for Dupuytren Contracture: A Propensity-matched Cohort of 16,888 Patients.Plastic and reconstructive surgery. Global open · 2026Article
- Determining Risk Factors and Rate of Surgery After Collagenase Injections for Dupuytren Contracture.Journal of hand surgery global online · 2025Article
- Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases.Pharmaceutics · 2025Review
- Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection.Hand (New York, N.Y.) · 2023Article
- A novel computationally engineered collagenase reduces the force required for tooth extraction in an ex-situ porcine jaw model.Journal of biological engineering · 2023Article
- Secretion of collagenases by Saccharomyces cerevisiae for collagen degradation.Biotechnology for biofuels and bioproducts · 2022Article
- Real-world Medicare Healthcare Costs of Patients with Dupuytren's Contracture Treated with Collagenase or Fasciectomy.Plastic and reconstructive surgery. Global open · 2022Article
- Article
- Collagenase Administration into Periodontal Ligament Reduces the Forces Required for Tooth Extraction in an Ex situ Porcine Jaw Model.Journal of functional biomaterials · 2022Article
- Article
- Screening Collagenase Activity in Bacterial Lysate for Directed Enzyme Applications.International journal of molecular sciences · 2021Article
- Collagen I Based Enzymatically Degradable Membranes for Organ-on-a-Chip Barrier Models.ACS biomaterials science & engineering · 2021Article
- Targeting Cell Contractile Forces: A Novel Minimally Invasive Treatment Strategy for Fibrosis.Annals of biomedical engineering · 2020Article
- Can Collagenase Be Used in the Treatment of Adhesive Capsulitis?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Article
- Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery.Molecular pharmaceutics · 2018Review
- Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.Drug design, development and therapy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH).
methodsThis review is based on a literature review and practical experience.
resultsThis review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies.
conclusionCCH has an evolving role as one of the tools available for treating Dupuytren's disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.