Evidence map›Paper›PMID 27050661›Full record

ArticlePloS one2016

Simple and Versatile 3D Printed Microfluidics Using Fused Filament Fabrication.

Alex J L Morgan, Lorena Hidalgo San Jose, William D Jamieson, Jennifer M Wymant, Bing Song, Phil Stephens, David A Barrow, Oliver K Castell

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. A 3D Printer in the Lab: Not Only a Toy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. 3D Printed Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex J L MorganCardiff School of Engineering, Cardiff University, Queen's Building, The Parade, Cardiff, CF24 3AA, United Kingdom.
Lorena Hidalgo San JoseCardiff School of Engineering, Cardiff University, Queen's Building, The Parade, Cardiff, CF24 3AA, United Kingdom.
William D JamiesonSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Ave, Cardiff, CF10 3NB, United Kingdom.
Jennifer M WymantSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Ave, Cardiff, CF10 3NB, United Kingdom.
Bing SongOral and Biomedical Sciences, Cardiff Institute of Tissue Engineering and Repair, School of Dentistry, Cardiff University, Heath Park, Cardiff, CF14 4XY, United Kingdom.
Phil StephensOral and Biomedical Sciences, Cardiff Institute of Tissue Engineering and Repair, School of Dentistry, Cardiff University, Heath Park, Cardiff, CF14 4XY, United Kingdom.
David A BarrowCardiff School of Engineering, Cardiff University, Queen's Building, The Parade, Cardiff, CF24 3AA, United Kingdom.
Oliver K CastellSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Ave, Cardiff, CF10 3NB, United Kingdom.

Funding

European Research Council 243261
6 · The paper itself

Abstract

The uptake of microfluidics by the wider scientific community has been limited by the fabrication barrier created by the skills and equipment required for the production of traditional microfluidic devices. Here we present simple 3D printed microfluidic devices using an inexpensive and readily accessible printer with commercially available printer materials. We demonstrate that previously reported limitations of transparency and fidelity have been overcome, whilst devices capable of operating at pressures in excess of 2000 kPa illustrate that leakage issues have also been resolved. The utility of the 3D printed microfluidic devices is illustrated by encapsulating dental pulp stem cells within alginate droplets; cell viability assays show the vast majority of cells remain live, and device transparency is sufficient for single cell imaging. The accessibility of these devices is further enhanced through fabrication of integrated ports and by the introduction of a Lego®-like modular system facilitating rapid prototyping whilst offering the potential for novices to build microfluidic systems from a database of microfluidic components.

Indexed as

MicrofluidicsPrinting, Three-DimensionalCells, CulturedHumansStem Cells

Identifiers

PMID27050661
PMCPMC4822857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.