Evidence map›Paper›PMID 27050650›Full record

ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2016

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study.

Shin Kariya, Serdar Kaya, Ömer Hizli, Pelin Hizli, Kazunori Nishizaki, Michael M Paparella, Sebahattin Cureoglu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Evaluation of the Effects of Dyslipidemia on Hearing in Patients with Type 2 Diabetes Mellitus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  10. Article
  11. The association between obstructive sleep apnea and hearing loss: a cross-sectional analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Article
  12. Emerging options in immune-mediated hearing loss.Laryngoscope investigative otolaryngology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shin Kariya*Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A. †Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan ‡Department of Otolaryngology, Gebze Fatih State Hospital, Gebze, Kocaeli, Turkey §Department of Otolaryngology, Giresun A. Ilhan Ozdemir State Hospital, Giresun, Turkey ||Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, U.S.A. ¶Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, U.S.A.
Serdar Kaya
Ömer Hizli
Pelin Hizli
Kazunori Nishizaki
Michael M Paparella
Sebahattin Cureoglu

Funding

Pathology and pathogenesis of otitis media syndromic ear and Meniere's diseaseU24DC011968 · NIDCD · UNIVERSITY OF MINNESOTA · PI CUREOGLU, SEBAHATTIN · 2011 to 2015
$2.2M
NIDCD NIH HHS U24 DC011968
6 · The paper itself

Abstract

hypothesisWe hypothesized that, in archived human temporal bone samples from patients with systemic lupus erythematosus (SLE), a pathologic condition exists in the stria vascularis and cochlear hair cells.

backgroundSensorineural hearing loss is a common feature in SLE patients. However, the pathophysiologic mechanism of cochlear dysfunction is unclear.

methodsWe examined 15 temporal bone samples from 8 SLE patients, along with 17 samples from 10 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and eosin. We determined the area of the stria vascularis in a midmodiolar section of each cochlear turn. Then, we made cytocochleograms and calculated the percentage of missing inner and outer hair cells.

resultsThe area of the stria vascularis in our SLE group was significantly smaller than in our control group. The number of remaining inner hair cells in our SLE group was smaller than in our control group; however, the difference did not reach statistical significance. The loss of outer hair cells in our SLE group was significantly higher than in our control group. There was a tendency toward a positive correlation between the loss of cochlear hair cells and the duration of SLE.

conclusionThe stria vascularis and cochlear hair cells are affected in SLE patients. Our findings could provide the histopathologic basis for the cochlear dysfunction, including sensorineural hearing loss, experienced by SLE patients.

Indexed as

AdultCochleaFemaleHair Cells, AuditoryHearing Loss, SensorineuralHumansLupus Erythematosus, SystemicMaleMiddle AgedStria VascularisTemporal Bone

Identifiers

PMID27050650
PMCPMC4864109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.