ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2016
Vascular and Neuroepithelial Histopathology of the Saccule in Humans With Diabetes Mellitus.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Accuracy and Precision of the Subjective Visual Vertical According to Age in Adults With/Without Diabetes.Diagnostics (Basel, Switzerland) · 2026Article
- Otolith Deterioration: Factors Affecting Microvascular and Structural Integrity.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Mechanisms of Vestibular System Damage in Diabetes Mellitus: Implications for Benign Paroxysmal Positional Vertigo Pathogenesis and Recurrence.Medical journal of the Islamic Republic of Iran · 2026Article
- Association between subtypes of diabetes and special sensations: A 2-sample Mendelian randomization study.Medicine · 2025Article
- Association of Peripheral Vestibular Disorder with Diabetes: A Population-Based Study.Journal of personalized medicine · 2024Article
- Diabetes Mellitus and Hearing Loss: A Complex Relationship.Medicina (Kaunas, Lithuania) · 2023Review
- When, where, and why should we look for vestibular dysfunction in people with diabetes mellitus?Frontiers in rehabilitation sciences · 2023Review
- Vestibular function for children with insulin dependent diabetes using cervical vestibular evoked myogenic potentials testing.World journal of clinical pediatrics · 2022Article
- Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly.International archives of otorhinolaryngology · 2020Article
- Diabetes and Auditory-Vestibular Pathology.Seminars in hearing · 2019Review
- Vestibular evoked myogenic potentials in patients with diabetes mellitus.Journal of otology · 2019Review
- Utricular hypofunction in patients with type 2 diabetes mellitus.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2017Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
hypothesisThis study aimed to determine if there are quantitative differences in the neuroepithelium and microvasculature of the saccule between subjects with and without diabetes mellitus (DM).
backgroundHistopathologic changes that may underlie the association between DM and vestibular dysfunction have not been characterized in humans.
methodsHuman temporal bones (HTBs) from 39 subjects with DM (n = 16 type I DM [T1DM], n = 23 type II DM [T2DM]) were compared with 40 group age-matched controls. Vessel wall thickness was measured from the saccular arteriole. Type I and type II vestibular hair cell (VHC) counts were performed on perpendicularly oriented saccular maculae using differential interference contrast microscopy (T1DM: 5HTB/3 subjects; T2DM: 9HTB/8 subjects; controls: 25HTB/20 subjects).
resultsThe mean density of type I VHCs was 16 to 17% lower in the DM groups compared to controls (T1DM 52.21 [4.26], T2DM 53.3 [5.34], control 63.14 [2.49] cells/mm, p = 0.02). There were no differences between T1DM, T2DM, and control groups in type II VHC density (T1DM 40.89 [5.17], T2DM 40.44 [6.93], control 42.80 [1.79] cells/mm, p = 0.92) or in mean vessel wall thickness (T1DM 2.23 [0.62], T2DM 2.18 [0.53], control 2.00 [0.53] μm, p = 0.26).
conclusionNeuroepithelial pathology, manifested as lower density of type I VHCs, was observed in the saccules of subjects with DM. Saccular microangiopathy, expressed as alterations in arteriole thickness, was not observed. These findings are consistent with histologic observations in animals with experimentally induced diabetes. DM may have a selective and deleterious effect on human vestibular sensory epithelia.
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