ArticleOncotarget2016
Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Diagnostic value of plasma RNF180 gene methylation for gastric cancer: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- A methylation panel of 10 CpGs for accurate age inference via stepwise conditional epigenome-wide association study.International journal of legal medicine · 2025Article
- RNF180 weakened the lipid droplet formation and subsequent chemoresistance by destabilizing ACC1 and ACLY in esophageal cancer.Frontiers in pharmacology · 2025Article
- Non-improvement of atrophic gastritis in cases of gastric cancer after successfulWorld journal of clinical cases · 2024Article
- DNA methylation biomarkers for early detection of gastric and colorectal cancers.Cancer biology & medicine · 2024Article
- Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer.Cancer communications (London, England) · 2023Article
- Droplet digital polymerase chain reaction assay for methylated ring finger protein 180 in gastric cancer.World journal of gastrointestinal oncology · 2022Article
- Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer.BioMed research international · 2022Article
- Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer.Cellular and molecular life sciences : CMLS · 2021Review
- Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Predictive value of risk score using Kyoto classification of gastritis a few years prior to diagnosis of early gastric cancer.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Circulating methylated Septin 9 and ring finger protein 180 for noninvasive diagnosis of early gastric cancer.Translational cancer research · 2020Article
- Ring finger protein 180 is associated with biological behavior and prognosis in patients with non-small cell lung cancer.Oncology letters · 2020Article
- Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer.Cancer management and research · 2020Article
- Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Promoter methylation (PM) of RING-finger protein (RNF) 180 affects gastric cancer (GC) prognosis, but its association with risk of GC or atrophic gastritis (AG) is unclear. We investigated relationships between RNF180 PM and GC or AG, and the effects of Helicobactor pylori (H.pylori) infection on RNF180 PM. This study included 513 subjects (159 with GC, 186 with AG, and 168 healthy controls [CON]) for RNF180 PM analysis, and another 55 GC patients for RNF180 gene expression analysis. Methylation was quantified using average methylation rates (AMR), methylated CpG site counts (MSC) and hypermethylated CpG site counts (HSC). RNF180 promoter AMR and MSC increased with disease severity. Optimal cut-offs were GC + AG: AMR > 0.153, MSC > 4 or HSC > 1; GC: AMR > 0.316, MSC > 15 and HSC > 6. Hypermethylation at 5 CpG sites differed significantly between GC/AG and CON groups, and was more common in GC patients than AG and CON groups for 2 other CpG sites. The expression of RNF180 mRNA levels in tumor were significantly lower than those in non-tumor, with the same as in hypermethylation than hypomethylation group. H.pylori infection increased methylation in normal tissue or mild gastritis, and increased hypermethylation risk at 3 CpG sites in AG. In conclusion, higher AMR, MSC and HSC levels could identify AG + GC or GC. Some RNF180 promoter CpG sites could identify precancerous or early-stage GC. H.pylori affects RNF180 PM in normal tissue or mild gastritis, and increases hypermethylation in 3 CpG sites in AG.
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