ArticleThe American journal of case reports2016
Clostridium Perfringens Infection in a Febrile Patient with Severe Hemolytic Anemia.
Article in The American journal of case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Clostridium perfringens-Induced Emphysematous Pyelonephritis: A Diagnostic Challenge With Negative Urine Culture.Cureus · 2025Article
- Liver abscess and septic shock due toFrontiers in medicine · 2025Article
- Article
- Hematological investigations in a case of intravascular hemolysis due toBiochemia medica · 2024Article
- Survival in a Case of Emphysematous Cholecystitis With Sepsis Caused by Clostridium perfringens.Cureus · 2023Article
- Clinical and Microbiological Features of Fulminant Haemolysis Caused byMicroorganisms · 2023Review
- Article
- Massive intravascular hemolysis is an important factor in Clostridium perfringens-induced bacteremia.Internal and emergency medicine · 2022Article
- Case report: Whole genome sequence ofFrontiers in microbiology · 2022Article
- The MAL Protein, an Integral Component of Specialized Membranes, in Normal Cells and Cancer.Cells · 2021Review
- A Gas-forming Liver Abscess with Massive Bleeding into the Abscess Cavity Due to a Ruptured Inferior Phrenic Artery.Internal medicine (Tokyo, Japan) · 2021Article
- Fulminant Haemolysis Following Endoscopic Retrograde Cholangiopancreatography.European journal of case reports in internal medicine · 2021Article
- Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure.Journal of cellular and molecular medicine · 2020Article
- Type A fulminant Clostridium perfringens sepsis indicated RBC/Hb discrepancy; a case report.BMC infectious diseases · 2019Article
- Septic Shock Due to Clostridium perfringens.Cureus · 2019Article
- Gaseous liver abscess withPrzeglad gastroenterologiczny · 2019Article
- Clostridium paraputrificum septicemia and liver abscess.World journal of hepatology · 2018Article
- Clostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation.Scientific reports · 2017Article
- Complete genome sequence ofGut pathogens · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClostridium perfringens (C. perfringens) can cause various infections, including gas gangrene, crepitant cellulitis, and fasciitis. While C. perfringens sepsis is uncommon, it is often rapidly fatal because the alpha toxin of this bacterium induces massive intravascular hemolysis by disrupting red blood cell membranes. CASE REPORT: We present the case of a male patient with diabetes who developed a fatal liver abscess with massive intravascular hemolysis and septic shock caused by toxigenic C. perfringens. The peripheral blood smear showed loss of central pallor, with numerous spherocytes. Multiplex PCR only detected expression of the cpa gene, indicating that the pathogen was C. perfringens type A.
conclusionsC. perfringens infection should be considered in a febrile patient who has severe hemolytic anemia with a very low MCV, hemolyzed blood sample, and negative Coombs test. The characteristic peripheral blood smear findings may facilitate rapid diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.