Evidence map›Paper›PMID 27049477›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Plasma Copeptin, AVP Gene Variants, and Incidence of Type 2 Diabetes in a Cohort From the Community.

Ronan Roussel, Ray El Boustany, Nadine Bouby, Louis Potier, Frédéric Fumeron, Kamel Mohammedi, Beverley Balkau, Jean Tichet, Lise Bankir, Michel Marre and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07789847 (Does Altering Daily Fluid Intake and Hydration Status Influence Cortisol Reactivity to Acute Psychosocial Stress?), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07789847 narecruitingnot on this mapstarted 2026, after this paper: background citation

Does Altering Daily Fluid Intake and Hydration Status Influence Cortisol Reactivity to Acute Psychosocial Stress?

TypeinterventionalSponsorLiverpool John Moores UniversityRan2026 to 2027Enrolled192ConditionsHydration Status, Psychosocial Stress, Fluid IntakeArmsModifying daily total fluid intake
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Ronan RousselINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Ray El BoustanyINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Nadine BoubyINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Louis PotierINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Frédéric FumeronINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Kamel MohammediINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Beverley BalkauINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Jean TichetINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Lise BankirINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Michel MarreINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Gilberto VelhoINSERM, UMR_S 1138, Centre de Recherche des Cordeliers (R.R., R.E.B., N.B., L.P., F.F., K.M., L.B., M.M., G.V.), 75006 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, and Assistance Publique Hôpitaux de Paris, Hôpital Bichat, Département Hospitalo-Universitaire FIRE, Service de Diabétologie, Endocrinologie et Nutrition (R.R., L.P., K.M., M.M.), 75018 Paris, France; Sorbonne Universités, Université Pierre et Marie Curie - Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers (R.E.B., N.B., L.B.), 75006 Paris, France; INSERM Unité de Recherche 1018, Centre de Recherche en Epidémiologie et Santé des Populations, and Université Paris Sud (B.B.), 94800 Villejuif, France; and IRSA (J.T.), 37520 La Riche, France.
Inserm · FRCentre de Recherche des Cordeliers · FRAssistance Publique – Hôpitaux de Paris · FRDélégation Paris 7 · FRSorbonne Université · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextExperimental data support a role for vasopressin in metabolic disorders.

objectiveWe investigated associations of plasma copeptin, a surrogate of vasopressin, and of allelic variations in the arginine vasopressin-neurophysin II gene with insulin secretion, insulin sensitivity, and the risk for impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). DESIGN, SETTING, AND

participantsWe studied 5110 unrelated French men and women from a prospective cohort of the general population (Data from Epidemiological Study on the Insulin Resistance Syndrome cohort, 9-y follow-up). Six single nucleotide polymorphisms were genotyped.

main outcome measureIncidence of IFG or T2DM during follow-up.

resultsThe incidence of hyperglycemia (IFG/T2DM) during follow-up by quartiles of baseline plasma copeptin was 11.0% (Q1), 14.5% (Q2), 17.0% (Q3), and 23.5% (Q4), log-rank test P = .003. Participants in the upper quartile of plasma copeptin had significantly lower insulin sensitivity (homeostasis model assessment index) at baseline and during follow-up, as compared with other participants. Cox proportional hazards regression analyses showed significant associations of the CC genotype of rs6084264, the TT genotype of rs2282018, the C-allele of rs2770381, and the CC genotype of rs1410713 with the incidence of hyperglycemia. The genotypes associated with an increased risk of hyperglycemia were also associated with increased plasma copeptin in men but not in women.

conclusionsHigh plasma copeptin was associated with reduced insulin sensitivity and an increased risk for IFG/T2DM diabetes in this community-based cohort. Moreover, in men, allelic associations support a causal role for vasopressin in these disorders.

Indexed as

Polymorphism, Single NucleotideAdultAllelesArginine VasopressinBlood GlucoseCohort StudiesDiabetes Mellitus, Type 2FemaleFranceGenetic Association StudiesGlycopeptidesHumansHyperglycemiaIncidenceInsulinInsulin ResistanceArginine VasopressinBlood GlucosecopeptinsGlycopeptidesInsulin

Identifiers

PMID27049477
PMCPMC4891798
OpenAlexW2322669667

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Registered trials

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