ArticleBiochemical and biophysical research communications2016
Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABAA/C receptors.
Article in Biochemical and biophysical research communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- In Vivo Irritation and Sensitization Assessment of Cypermethrin, Pymetrozine, and Indoxacarb-Emamectin Benzoate Combination in Test Animals.Journal of toxicology · 2025Article
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- Phenotypic Profiling of Macrocyclic Lactones on ParasiticAntimicrobial agents and chemotherapy · 2023Article
- ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation.FASEB bioAdvances · 2022Article
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- Interaction of HaNPVs with two novel insecticides againstSaudi journal of biological sciences · 2020Article
- Combined effect of furanone fluconazole and amphotericin B against biofilms formed from Cryptococcus neoformans.Bioinformation · 2020Article
- Molecular docking analysis of timepidium with Acetylcholine and lumacaftor with GABA(A) activator.Bioinformation · 2019Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Avermectins are a group of compounds isolated from a soil-dwelling bacterium. They have been widely used as parasiticides and insecticides, acting by relatively irreversible activation of invertebrate chloride channels. Emamectin is a soluble derivative of an avermectin. It is an insecticide, which persistently activates glutamate-gated chloride channels. However, its effects on mammalian ligand-gated ion channels are unknown. To this end, we tested the effect of emamectin on two cation selective nicotinic receptors and two GABA-gated chloride channels expressed in Xenopus oocytes using two-electrode voltage clamp. Our results demonstrate that emamectin could directly activate α7 nAChR, α4β2 nAChR, α1β2γ2 GABAA receptor and ρ1 GABAC receptor concentration dependently, with similar potencies for each channel. However, the potencies for it to activate these channels were at least two orders of magnitude lower than its potency of activating invertebrate glutamate-gated chloride channel. In contrast, ivermectin only activated the α1β2γ2 GABAA receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.