Evidence map›Paper›PMID 27049062›Full record

ArticleMucosal immunology2017

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.

A Gibbs, E Leeansyah, A Introini, D Paquin-Proulx, K Hasselrot, E Andersson, K Broliden, J K Sandberg, A Tjernlund

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.

  1. Pooled it
  2. Persistent, Asymptomatic Colonization withMicrobiology spectrum · 2022
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  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Gastrointestinal MAIT cells in chronic HIV-1 infection.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  15. Review
  16. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
    Review
  17. Review
  18. Review
  19. Review
  20. Article

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

A GibbsUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
E LeeansyahCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
A IntroiniUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
D Paquin-ProulxCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
K HasselrotUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
E AnderssonDepartment of Clinical Pathology/Cytology, Capio St Göran Hospital, Stockholm, Sweden.
K BrolidenUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
J K SandbergCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
A TjernlundUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SESaint Göran Hospital · SE

Funding

Intestinal MAIT Cells in HIV InfectionR01DK108350 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PAQUIN-PROULX, DOMINIC, SANDBERG, JOHAN K · 2015 to 2019
$2.5M
NIDDK NIH HHS R01 DK108350
6 · The paper itself

Abstract

The female genital tract (FGT) mucosa is a critically important site for immune defense against microbes. Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population that recognizes microbial riboflavin metabolite antigens in an MR1-dependent manner. The role of MAIT cells in the FGT mucosa is unknown. Here, we found that MAIT cells and MR1

Indexed as

Immunity, InnateAdultAntigens, BacterialCells, CulturedCervix UteriEndometriumEscherichia coliFemaleHistocompatibility Antigens Class IHumansInterleukin-17Interleukin-22Interleukin-7 Receptor alpha SubunitInterleukinsMiddle AgedMinor Histocompatibility AntigensAntigens, BacterialHistocompatibility Antigens Class IInterleukin-17Interleukin-22Interleukin-7 Receptor alpha SubunitInterleukinsMinor Histocompatibility AntigensMR1 protein, humanNuclear Receptor Subfamily 1, Group F, Member 3Riboflavin

Identifiers

PMID27049062
PMCPMC5053908
OpenAlexW2313070720

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.