Evidence map›Paper›PMID 27048961›Full record

ReviewNeuroscience and biobehavioral reviews2016

Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models.

Judith R Homberg, Evan J Kyzar, Michael Nguyen, William H Norton, Julian Pittman, Manoj K Poudel, Siddharth Gaikwad, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi and 12 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
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  6. Article
  7. The Ambiguous Role of Growth Factors in Autism: What Do We Really Know?International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Current State of Modeling Human Psychiatric Disorders Using Zebrafish.International journal of molecular sciences · 2023
    Review
  16. [Recent research on neurodevelopmental disorders in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
  17. Article
  18. Review
  19. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Judith R HombergDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands.
Evan J KyzarDepartment of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA; The International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Michael NguyenThe International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA; New York University School of Medicine, NY, NY, USA.
William H NortonDepartment of Biology, University of Leicester, Leicester, UK.
Julian PittmanDepartment of Biological and Environmental Sciences, Troy University, Troy, AL, USA.
Manoj K PoudelThe International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Siddharth GaikwadThe International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Shun NakamuraTokyo University of Agriculture and Technology, Tokyo, Japan.
Mamiko KoshibaDepartments of Pediatrics and Biochemistry, Saitama Medical University, Saitama, Japan.
Hideo YamanouchiDepartments of Pediatrics and Biochemistry, Saitama Medical University, Saitama, Japan.
Maria Luisa ScattoniDepartment of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy.
Jeremy F P UllmanCentre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
David M DiamondDepartment of Psychology, University of South Florida, Tampa, FL, USA; J.A. Haley Veterans Hospital, Research and Development Service, Tampa, FL, USA.
Aleksandra A KaluyevaThe International Stress and Behavior Society (ISBS) and ZENEREI Research Center, Slidell, LA, USA.
Matthew O ParkerSchool of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK.
Victor M KlimenkoPavlov Physiology Department, Institute of Experimental Medicine IEM RAS, St. Petersburg, Russia.
Sergey A ApryatinResearch Institute of Nutrition RAS, Moscow, Russia.
Richard E BrownDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
Cai SongDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada; Research Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Graduate Neuroscience Institute, China Medical University Hospital, Taichung, Taiwan.
Raul R GainetdinovInstitute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Skolkovo Institute of Science and Technology, Skolkovo, Moscow Region, Russia.
Irving I GottesmanDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Allan V KalueffResearch Institute of Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institutes of Chemical Technology and Natural Sciences, Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.

Indexed as

Autistic DisorderNeurodevelopmental DisordersAnimalsAutism Spectrum DisorderBrainNeurogenesisExperimental modelModel organismNeurodevelopmental disorderPreclinical studyTranslational research

Identifiers

PMID27048961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.