ArticleScientific reports2016
Integrated Metabolomics Study of the Milk of Heat-stressed Lactating Dairy Cows.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 115 citations in OpenAlex.
- Integrated Rumen Metabolomics and Metagenomics Reveal Microbe-Metabolite Signatures Associated with Heat Tolerance in Dairy Cows.Animals : an open access journal from MDPI · 2026Article
- Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Plasma Biochemistry.Animals : an open access journal from MDPI · 2026Article
- Understanding Climate Change Threats to Vertebrate Wildlife by Studying Ecoimmunology Across Biological Scales.Integrative and comparative biology · 2025Review
- Metabolomic signatures reveal mechanisms of rumen-protected glutathione in mitigating oxidative stress and regulating inflammatory networks in transition dairy cows.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Heat stress compromises nutritional quality and flavor of bovine raw milk: Evidence from multi-omics analyses.Food chemistry: X · 2025Article
- A Recursive Model Approach to Include Epigenetic Effects in Genetic Evaluations Using Simulated DNA Methylation Effects.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways.Genetics, selection, evolution : GSE · 2025Article
- Circulating serum metabolites as biomarkers and predictors of residual feed intake in lactating dairy cows.Scientific reports · 2025Article
- Heat Tolerance Differences Between Hu Sheep and Hu Crossbred Sheep in Microbial Community Structure and Metabolism.Metabolites · 2025Article
- Mid infrared spectroscopy combined with chemometrics as tool to monitor the impact of heat stress and dietary interventions in lactating sows.International journal of biometeorology · 2025Article
- Heat stress affects mammary metabolism by influencing the plasma flow to the glands.Journal of animal science and biotechnology · 2024Article
- Heat Stress Effects on Physiological and Milk Yield Traits of Lactating Holstein Friesian Crossbreds Reared in Tanga Region, Tanzania.Animals : an open access journal from MDPI · 2024Article
- The Impacts of Heat Stress on Rumination, Drinking, and Locomotory Behavior, as Registered by Innovative Technologies, and Acid-Base Balance in Fresh Multiparous Dairy Cows.Animals : an open access journal from MDPI · 2024Article
- Physiological impact of amino acids during heat stress in ruminants.Animal frontiers : the review magazine of animal agriculture · 2023Article
- Effects of ultra-high-temperature processes on metabolite changes in milk.Food science & nutrition · 2023Article
- A Pilot Study on Across-Generation Impacts of Maternal Heat Stress on Blood Metabolites of Female Holstein Dairy Calves.Metabolites · 2023Article
- Genes and models for estimating genetic parameters for heat tolerance in dairy cattle.Frontiers in genetics · 2023Review
- Heat stress effects on milk yield traits and metabolites and mitigation strategies for dairy cattle breeds reared in tropical and sub-tropical countries.Frontiers in veterinary science · 2023Review
- Milk metabolomics analyses of lactating dairy cows with divergent residual feed intake reveals physiological underpinnings and novel biomarkers.Frontiers in molecular biosciences · 2023Article
- Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) damages the global dairy industry by reducing milk yields and quality, harming health, and damaging the reproduction of dairy cows, causing huge economic losses each year. However, an understanding of the physiological mechanism of HS lactating dairy cows remains elusive. Here, a metabolomics study using LC-MS and (1)H NMR spectroscopy was performed to analyze the metabolomic differences in the milk between HS-free and HS dairy cows, and discover diagnostic biomarkers and changes in the metabolic pathway. A total of 53 discriminating metabolites were significantly up- or down-regulated in the HS group compared with the HS-free group (P < 0.05). These biomarkers were involved in pathways of carbohydrate, amino acid, lipid, and gut microbiome-derived metabolism. Comparing these potential biomarkers with previously identified HS candidate biomarkers in plasma, significant correlations between the levels of lactate, pyruvate, creatine, acetone, β-hydroxybutyrate, trimethylamine, oleic acid, linoleic acid, lysophosphatidylcholine 16:0, and phosphatidylcholine 42:2 in milk and plasma were found, indicating that the blood-milk barrier became leaky and the levels of these 10 biomarkers in milk can reflect HS-induced metabolomic alterations in blood. These novel findings can support more in-depth research to elucidate the milk-based changes in metabolic pathways in HS lactating dairy cows.
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