ArticleNature communications2016
Catalytic N-radical cascade reaction of hydrazones by oxidative deprotonation electron transfer and TEMPO mediation.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Direct generation of nitrogen-centered radicals via non-covalent interaction between Cu complexes and BiVONature communications · 2025Article
- Enhanced Photoredox Activity in Nitrogen-Doped Carbon Nitride for Heterogeneous Nitrogen and Oxygen Radical Reactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Illuminating Palladium Catalysis.Accounts of chemical research · 2025Article
- Formal [4 + 2] combined ionic and radical approach of vinylogous enaminonitriles to access highly substituted sulfonyl pyridazines.Communications chemistry · 2024Article
- Synthesis of substituted benzylboronates by light promoted homologation of boronic acids withChemical science · 2023Article
- Energy-transfer-induced [3+2] cycloadditions of N-N pyridinium ylides.Nature chemistry · 2023Article
- Modular synthesis of unsaturated aza-heterocycles via copper catalyzed multicomponent cascade reaction.iScience · 2023Article
- Visible-light-induced indole synthesisChemical science · 2022Article
- Metal-Catalyzed, Photo-Assisted Selective Transformation of Tertiary Alkylbenzenes and Polystyrenes into Carbonyl Compounds.ChemSusChem · 2022Article
- Photocatalytic cyclization of nitrogen-centered radicals with carbon nitride through promoting substrate/catalyst interaction.Nature communications · 2022Article
- Recent advances in visible light-induced C(Nature reviews. Chemistry · 2022Article
- Highly Selective Synthesis of Seven-Membered Azaspiro Compounds by a Rh(I)-Catalyzed Cycloisomerization/Diels-Alder Cascade of 1,5-Bisallenes.The Journal of organic chemistry · 2022Article
- Article
- Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis.Chemical reviews · 2022Review
- Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis.Chemical reviews · 2022Review
- Brønsted acid-promoted hydroamination of unsaturated hydrazones: access to biologically important 5-arylpyrazolines.RSC advances · 2021Article
- Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Cathodic electroorganic reaction on silicon oxide dielectric electrode.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Synthesis ofChemical science · 2020Article
- Dichloromethylation of enones by carbon nitride photocatalysis.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared with the popularity of various C-centred radicals, the N-centred radicals remain largely unexplored in catalytic radical cascade reactions because of a lack of convenient methods for their generation. Known methods for their generation typically require the use of N-functionalized precursors or various toxic, potentially explosive or unstable radical initiators. Recently, visible-light photocatalysis has emerged as an attractive tool for the catalytic formation of N-centred radicals, but the pre-incorporation of a photolabile groups at the nitrogen atom largely limited the reaction scope. Here, we present a visible-light photocatalytic oxidative deprotonation electron transfer/2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediation strategy for catalytic N-radical cascade reaction of unsaturated hydrazones. This mild protocol provides a broadly applicable synthesis of 1,6-dihydropyradazines with complete regioselectivity and good yields. The 1,6-dihydropyradazines can be easily transformed into diazinium salts that showed promising in vitro antifungal activities against fungal pathogens. DFT calculations are conducted to explain the mechanism.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.